MMP10

Target id: 1634

Nomenclature: MMP10

Family: M10: Matrix metallopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 476 11q22.3 MMP10 matrix metallopeptidase 10 (stromelysin 2)
Mouse - 476 9 A1 Mmp10 matrix metallopeptidase 10
Rat - 476 8q11 Mmp10 matrix metallopeptidase 10
Previous and Unofficial Names
transin-2
SL-2
transformation-associated protein 34A
STMY2
matrix metallopeptidase 10 (stromelysin 2)
Database Links
Specialist databases
MEROPS M10.006 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
ExplorEnz
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Enzyme
KEGG Gene
NeXtProt
OMIM
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Enzyme Reaction
EC Number: 3.4.24.22
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CM-352 Hs Inhibition 7.82 pIC50 1
pIC50 7.82 (IC50 1.5x10-8 M) [1]

References

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1. Orbe J, Rodríguez JA, Sánchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Páramo JA. (2015) Discovery and Safety Profiling of a Potent Preclinical Candidate, (4-[4-[[(3R)-3-(Hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the Prevention and Treatment of Hemorrhage. J. Med. Chem.,  [Epub ahead of print]. [PMID:25686022]

How to cite this page

M10: Matrix metallopeptidase: MMP10. Last modified on 12/03/2015. Accessed on 03/08/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1634.