MMP14

Target id: 1638

Nomenclature: MMP14

Family: M10: Matrix metallopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     MMP14 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 582 14q11-q12 MMP14 matrix metallopeptidase 14
Mouse - 582 14 C2 Mmp14 matrix metallopeptidase 14 (membrane-inserted)
Rat - 582 15p13 Mmp14 matrix metallopeptidase 14
Previous and Unofficial Names
MMP- X1 | membrane type 1 metalloprotease | membrane-type matrix metalloproteinase 1 | MT1MMP | MTMMP1 | Membrane type 1-MMP | matrix metallopeptidase 14 (membrane-inserted)
Database Links
Specialist databases
MEROPS M10.014 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.80

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 29e [PMID: 23631440] Hs Inhibition 8.4 pKi 1
pKi 8.4 (Ki 4x10-9 M) [1]
ilomastat Hs Inhibition 7.6 pIC50 2
pIC50 7.6 (IC50 2.3x10-8 M) [2]
CGS-27023A Hs Inhibition 7.6 pIC50 3
pIC50 7.6 (IC50 2.3x10-8 M) [3]
Immunopharmacology Comments
MMP14 is included in GtoImmuPdb based on its contribution to degradation of collagenous cartilage matrix in rheumatoid arthritis.
Immuno Process Associations
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of B cell differentiation (GO:0045579) ISS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of B cell differentiation (GO:0045579) ISS
positive regulation of macrophage migration (GO:1905523) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of B cell differentiation (GO:0045579) ISS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of B cell differentiation (GO:0045579) ISS
References: 
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of macrophage migration (GO:1905523) IEA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of macrophage migration (GO:1905523) IEA
References: 
Immuno Disease Associations
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonynms
Comment:  MMP14 (also called MT1-MMP) is highly expressed in fibroblast-like synoviocytes and macrophages from patients with RA, and is reckoned to be one of the main MMPs involved in degradation of collagenous cartilage matrix
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  4-5
Clinically-Relevant Mutations and Pathophysiology
Disease:  Multicentric osteolysis, nodulosis, and arthropathy
Synonyms: Nodulosis-arthropathy-osteolysis syndrome [Orphanet: ORPHA85196]
OMIM: 259600
Orphanet: ORPHA85196
Disease:  Winchester syndrome
OMIM: 277950
Orphanet: ORPHA3460

References

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1. Jin Y, Roycik MD, Bosco DB, Cao Q, Constantino MH, Schwartz MA, Sang QX. (2013) Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J. Med. Chem.56 (11): 4357-73. [PMID:23631440]

2. Ma D, Wu W, Yang G, Li J, Li J, Ye Q. (2004) Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg. Med. Chem. Lett.14 (1): 47-50. [PMID:14684295]

3. Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E et al.. (2011) Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem46 (7): 2617-29. [PMID:21514700]

4. Pap T, Shigeyama Y, Kuchen S, Fernihough JK, Simmen B, Gay RE, Billingham M, Gay S. (2000) Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis. Arthritis Rheum.43 (6): 1226-32. [PMID:10857781]

5. Sabeh F, Fox D, Weiss SJ. (2010) Membrane-type I matrix metalloproteinase-dependent regulation of rheumatoid arthritis synoviocyte function. J. Immunol.184 (11): 6396-406. [PMID:20483788]

How to cite this page

M10: Matrix metallopeptidase: MMP14. Last modified on 19/04/2017. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1638.