MMP17

Target id: 1641

Nomenclature: MMP17

Family: M10: Matrix metallopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for MMP17 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 603 12q24.3 MMP17 matrix metallopeptidase 17
Mouse - 578 5 G1.3 Mmp17 matrix metallopeptidase 17
Rat - 587 12q13 Mmp17 matrix metallopeptidase 17
Previous and Unofficial Names
MT4-MMP | membrane type-4 matrix metalloproteinase | matrix metallopeptidase 17 (membrane-inserted)
Database Links
Specialist databases
MEROPS M10.017 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ilomastat Hs Inhibition 8.5 pIC50 1
pIC50 8.5 (IC50 3.4x10-9 M) [1]

References

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1. Johnson AR, Pavlovsky AG, Ortwine DF, Prior F, Man CF, Bornemeier DA, Banotai CA, Mueller WT, McConnell P, Yan C et al.. (2007) Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J. Biol. Chem.282 (38): 27781-91. [PMID:17623656]

How to cite this page

M10: Matrix metallopeptidase: MMP17. Last modified on 16/03/2017. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1641.