MMP17 | M10: Matrix metallopeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

MMP17

Target id: 1641

Nomenclature: MMP17

Family: M10: Matrix metallopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for MMP17 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 603 12q24.3 MMP17 matrix metallopeptidase 17
Mouse - 578 5 G1.3 Mmp17 matrix metallopeptidase 17
Rat - 587 12q13 Mmp17 matrix metallopeptidase 17
Previous and Unofficial Names
MT4-MMP | membrane type-4 matrix metalloproteinase | matrix metallopeptidase 17 (membrane-inserted)
Database Links
Specialist databases
MEROPS M10.017 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ilomastat Hs Inhibition 8.5 pIC50 1
pIC50 8.5 (IC50 3.4x10-9 M) [1]

References

Show »

1. Johnson AR, Pavlovsky AG, Ortwine DF, Prior F, Man CF, Bornemeier DA, Banotai CA, Mueller WT, McConnell P, Yan C et al.. (2007) Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J. Biol. Chem., 282 (38): 27781-91. [PMID:17623656]

How to cite this page

M10: Matrix metallopeptidase: MMP17. Last modified on 16/03/2017. Accessed on 21/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1641.