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P2RY10

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Target not currently curated in GtoImmuPdb

Target id: 165

Nomenclature: P2RY10

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 339 Xq21.1 P2RY10 P2Y receptor family member 10
Mouse 7 328 X D P2ry10 purinergic receptor P2Y, G-protein coupled 10
Rat 7 388 Xq31 P2ry10 P2Y receptor family member 10
Previous and Unofficial Names Click here for help
purinergic receptor P2Y10 | purinergic receptor P2Y, G-protein coupled 10 | purinergic receptor P2Y
Database Links Click here for help
Specialist databases
GPCRdb p2y10_human (Hs)
Other databases
Alphafold O00398 (Hs), Q8BFU7 (Mm)
ChEMBL Target CHEMBL3562166 (Hs), CHEMBL3562168 (Mm)
Ensembl Gene ENSG00000078589 (Hs), ENSMUSG00000050921 (Mm), ENSRNOG00000037839 (Rn)
Entrez Gene 27334 (Hs), 78826 (Mm), 317219 (Rn)
Human Protein Atlas ENSG00000078589 (Hs)
KEGG Gene hsa:27334 (Hs), mmu:78826 (Mm), rno:317219 (Rn)
OMIM 300529 (Hs)
Pharos O00398 (Hs)
RefSeq Nucleotide NM_014499 (Hs), NM_172435 (Mm), NM_001177682 (Rn)
RefSeq Protein NP_055314 (Hs), NP_766023 (Mm), NP_001171153 (Rn)
UniProtKB O00398 (Hs), Q8BFU7 (Mm)
Wikipedia P2RY10 (Hs)
Natural/Endogenous Ligands Click here for help
LPA
sphingosine 1-phosphate
Comments: Proposed ligands, single publication

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
sphingosine 1-phosphate Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Hs Agonist 7.3 pEC50 2
⤷ pEC50 7.3 [2]
LPA Small molecule or natural product Click here for species-specific activity table Ligand is endogenous in the given species Hs Agonist 6.9 pEC50 2
⤷ pEC50 6.9 [2]
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
dioctanoylglycerol pyrophosphate Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist - - 2
⤷ [2]
JTE-013 Small molecule or natural product Click here for species-specific activity table Hs Antagonist - - 2
⤷ [2]
Tissue Distribution Click here for help
Platelets
Expression level:  High
Species:  Human
Technique:  qRT-PCR (microarray analysis) and western blotting
References:  1
B-cells
Expression level:  High
Species:  Mouse
Technique:  Northern blot, subtractive hybridisation
References:  3
Placenta, uterus, prostate, brain, lung, and skeletal muscle
Expression level:  High
Species:  Mouse
Technique:  RT-PCR
References:  2
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  N3H
Global MAF (%):  19
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 7|24|49|1
Minor allele count:  C=0.187/311
SNP accession:  VAR_033481, rs6618868
Validation:  1000 Genomes, HapMap

References

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1. Amisten S, Braun OO, Bengtsson A, Erlinge D. (2008) Gene expression profiling for the identification of G-protein coupled receptors in human platelets. Thromb Res, 122 (1): 47-57. [PMID:17920662]

2. Murakami M, Shiraishi A, Tabata K, Fujita N. (2008) Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun, 371 (4): 707-12. [PMID:18466763]

3. Rao S, Garrett-Sinha LA, Yoon J, Simon MC. (1999) The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor. J Biol Chem, 274 (48): 34245-52. [PMID:10567398]

Contributors

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