ADAM8

Target id: 1656

Nomenclature: ADAM8

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     ADAM8 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 824 10q26.3 ADAM8 ADAM metallopeptidase domain 8
Mouse - 726 7 F3-F5 Adam8 a disintegrin and metallopeptidase domain 8
Rat - - 1q41 Adam8 ADAM metallopeptidase domain 8
Previous and Unofficial Names
Cell surface antigen MS2 | a disintegrin and metalloproteinase domain 8 | ADAM metallopeptidase domain 8 | CD156a
Database Links
Specialist databases
MEROPS M12.208 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
INCB3619 Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1x10-6 M) [1]
Immunopharmacology Comments
ADAM8 is reported to drive acute allergen-induced airway inflammation in a mouse model, and effect negated by ADAM8-deficiency (antibody-induced or gene knockout) [3]. The potential roles of ADAM8 in inflammation regulation and in experimental asthma are reviewed in [4] and [2] respectively.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  leukocyte migration involved in inflammatory response (GO:0002523) ISS
positive regulation of acute inflammatory response (GO:0002675) ISS
inflammatory response (GO:0006954) IDA
activation of MAPK activity involved in innate immune response (GO:0035419) ISS
neutrophil degranulation (GO:0043312) TAS
lymphocyte chemotaxis (GO:0048247) ISS
positive regulation of neutrophil extravasation (GO:2000391) IDA
positive regulation of fibronectin-dependent thymocyte migration (GO:2000415) ISS
positive regulation of eosinophil migration (GO:2000418) ISS
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell differentiation in thymus (GO:0033089) ISS
positive regulation of thymocyte apoptotic process (GO:0070245) ISS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of acute inflammatory response (GO:0002675) ISS
positive regulation of T cell differentiation in thymus (GO:0033089) ISS
activation of MAPK activity involved in innate immune response (GO:0035419) ISS
positive regulation of neutrophil extravasation (GO:2000391) IDA
positive regulation of fibronectin-dependent thymocyte migration (GO:2000415) ISS
positive regulation of eosinophil migration (GO:2000418) ISS
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell differentiation in thymus (GO:0033089) ISS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of tumor necrosis factor (ligand) superfamily member 11 production (GO:2000309) ISS
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  leukocyte migration involved in inflammatory response (GO:0002523) ISS
positive regulation of T cell differentiation in thymus (GO:0033089) ISS
lymphocyte chemotaxis (GO:0048247) ISS
positive regulation of neutrophil extravasation (GO:2000391) IDA
positive regulation of fibronectin-dependent thymocyte migration (GO:2000415) ISS
positive regulation of eosinophil migration (GO:2000418) ISS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell differentiation in thymus (GO:0033089) ISS
activation of MAPK activity involved in innate immune response (GO:0035419) ISS
neutrophil degranulation (GO:0043312) TAS
References: 

References

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1. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg. Med. Chem.16 (19): 8781-94. [PMID:18790648]

2. Matsuno O, Miyazaki E, Nureki S, Ueno T, Kumamoto T, Higuchi Y. (2006) Role of ADAM8 in experimental asthma. Immunol. Lett.102 (1): 67-73. [PMID:16154205]

3. Paulissen G, Rocks N, Guéders MM, Bedoret D, Crahay C, Quesada-Calvo F, Hacha J, Bekaert S, Desmet C, Foidart JM et al.. (2011) ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation. Eur. J. Immunol.41 (2): 380-91. [PMID:21268008]

4. Zarbock A, Rossaint J. (2011) Regulating inflammation: ADAM8--a new player in the game. Eur. J. Immunol.41 (12): 3419-22. [PMID:22125009]

How to cite this page

M12: Astacin/Adamalysin: ADAM8. Last modified on 31/01/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1656.