<i>TAAR3</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

TAAR3

Target id: 168

Nomenclature: TAAR3

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for TAAR3 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor: thought to be a pseudogene in man though functional in rodents
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 343 6q23-24 TAAR3P trace amine associated receptor 3, pseudogene 1
Mouse 7 343 10 A4 Taar3 trace amine-associated receptor 3
Rat 7 342 1p12 Taar3 trace amine-associated receptor 3
Previous and Unofficial Names
GPR57 | G protein-coupled receptor 57 | trace amine receptor 3 | TAAR3 | trace amine associated receptor 3 (gene/pseudogene)
Database Links
Specialist databases
GPCRDB taar3_human (Hs), taar3_mouse (Mm), taar3_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
Comments: probable pseudogene.

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
isoamylamine Mm Full agonist 5.0 pEC50 2
pEC50 5.0 (EC50 1x10-5 M) [2]
Agonist Comments
Cyclohexylamine has been shown to be an agonist at this receptor in mice [2]. It has been shown that the agonists of murine TAAR3 do not activate intact primate and mammalian orthologs [3].
Tissue Distribution
Olfactory epithelium
Species:  Mouse
Technique:  In situ hybridisation and RT-PCR.
References:  2
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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References

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1. Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. (2000) Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim. Biophys. Acta, 1490 (3): 311-23. [PMID:10684976]

2. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

3. Stäubert C, Böselt I, Bohnekamp J, Römpler H, Enard W, Schöneberg T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE, 5 (6): e11133. [PMID:20559446]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: TAAR3. Last modified on 31/07/2015. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=168.