Interleukin-2 receptor subunit α

Target id: 1695

Nomenclature: Interleukin-2 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-2 receptor subunit α has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-2 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 272 10p15.1 IL2RA interleukin 2 receptor subunit alpha
Mouse 1 268 Il2ra interleukin 2 receptor, alpha chain
Rat 1 267 Il2ra interleukin 2 receptor subunit alpha
Previous and Unofficial Names
CD25 | TAC antigen | IL2RAC | IL-2R alpha chain | Ly-43
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
daclizumab Hs Binding >8.0 pKd 1
pKd >8.0 (Kd <1x10-8 M) [1]
basiliximab Hs Binding - -
Immunopharmacology Comments
IL2RA is a ligand binding component of the IL-2R complex. This subunit is the molecular target of the approved biologics daclizumab (including daclizumab beta) and basiliximab.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  inflammatory response to antigenic stimulus (GO:0002437) IEA
inflammatory response (GO:0006954) IBA
negative regulation of inflammatory response (GO:0050728) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  regulation of T cell tolerance induction (GO:0002664) IMP
activation-induced cell death of T cells (GO:0006924) IEA
positive regulation of activated T cell proliferation (GO:0042104) IEA
negative regulation of T cell proliferation (GO:0042130) IEA
positive regulation of T cell differentiation (GO:0045582) IEA
regulation of T cell homeostatic proliferation (GO:0046013) IEA
negative regulation of defense response to virus (GO:0050687) IEA
negative regulation of inflammatory response (GO:0050728) IEA
negative regulation of immune response (GO:0050777) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  regulation of T cell tolerance induction (GO:0002664) IMP
positive regulation of T cell differentiation (GO:0045582) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-2 receptor activity (GO:0004911) IBA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  activation-induced cell death of T cells (GO:0006924) IEA
positive regulation of activated T cell proliferation (GO:0042104) IEA
negative regulation of T cell proliferation (GO:0042130) IEA
positive regulation of T cell differentiation (GO:0045582) IEA
regulation of T cell homeostatic proliferation (GO:0046013) IEA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of activated T cell proliferation (GO:0042104) IEA
negative regulation of T cell proliferation (GO:0042130) IEA
positive regulation of T cell differentiation (GO:0045582) IEA
regulation of T cell homeostatic proliferation (GO:0046013) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of activated T cell proliferation (GO:0042104) IEA
negative regulation of T cell proliferation (GO:0042130) IEA
positive regulation of T cell differentiation (GO:0045582) IEA
regulation of T cell homeostatic proliferation (GO:0046013) IEA
References: 

References

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1. Queen CL, Schneider WP, Selick HE. (1997) Genetic engineering; complementarity zones. Patent number: US5693761. Assignee: Protein Design Labs, Inc.. Priority date: 28/12/1988. Publication date: 02/12/1997.

How to cite this page

IL-2 receptor family: Interleukin-2 receptor subunit α. Last modified on 28/03/2017. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1695.