Interleukin-2 receptor subunit α

Target id: 1695

Nomenclature: Interleukin-2 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-2 receptor subunit α has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-2 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 272 10p15.1 IL2RA interleukin 2 receptor subunit alpha
Mouse 1 268 Il2ra interleukin 2 receptor
Rat 1 267 Il2ra interleukin 2 receptor subunit alpha
Previous and Unofficial Names
CD25 | TAC antigen | IL2RAC | IL-2R alpha chain | Ly-43
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
daclizumab Hs Binding >8.0 pKd 1
pKd >8.0 (Kd <1x10-8 M) [1]
basiliximab Hs Binding - -
Immunopharmacology Comments
IL2RA is a ligand binding component of the IL-2R complex. This subunit is the molecular target of the approved biologics daclizumab (including daclizumab beta) and basiliximab. Another anti-CD25 mAb, inolimomab, has received orphan drug designation from the EMA, for the treatment of graft-versus-host disease. Phase 3 findings for this drug and indication are reported in [2], the major conclusion being that the primary end point for the trial was not met (no statistical difference between the inolimomab and normal standard of care arms of the study).
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  inflammatory response to antigenic stimulus (GO:0002437) IEA
inflammatory response (GO:0006954) IBA
negative regulation of inflammatory response (GO:0050728) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  regulation of T cell tolerance induction (GO:0002664) IMP
activation-induced cell death of T cells (GO:0006924) IEA
positive regulation of activated T cell proliferation (GO:0042104) IEA
negative regulation of T cell proliferation (GO:0042130) IEA
positive regulation of T cell differentiation (GO:0045582) IEA
regulation of regulatory T cell differentiation (GO:0045589) TAS
regulation of T cell homeostatic proliferation (GO:0046013) IEA
negative regulation of defense response to virus (GO:0050687) IEA
negative regulation of inflammatory response (GO:0050728) IEA
negative regulation of immune response (GO:0050777) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  regulation of T cell tolerance induction (GO:0002664) IMP
positive regulation of T cell differentiation (GO:0045582) IEA
regulation of regulatory T cell differentiation (GO:0045589) TAS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-2 receptor activity (GO:0004911) IBA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  activation-induced cell death of T cells (GO:0006924) IEA
positive regulation of activated T cell proliferation (GO:0042104) IEA
negative regulation of T cell proliferation (GO:0042130) IEA
positive regulation of T cell differentiation (GO:0045582) IEA
regulation of regulatory T cell differentiation (GO:0045589) TAS
regulation of T cell homeostatic proliferation (GO:0046013) IEA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of activated T cell proliferation (GO:0042104) IEA
negative regulation of T cell proliferation (GO:0042130) IEA
positive regulation of T cell differentiation (GO:0045582) IEA
regulation of regulatory T cell differentiation (GO:0045589) TAS
regulation of T cell homeostatic proliferation (GO:0046013) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of activated T cell proliferation (GO:0042104) IEA
negative regulation of T cell proliferation (GO:0042130) IEA
positive regulation of T cell differentiation (GO:0045582) IEA
regulation of regulatory T cell differentiation (GO:0045589) TAS
regulation of T cell homeostatic proliferation (GO:0046013) IEA
References: 

References

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1. Queen CL, Schneider WP, Selick HE. (1997) Genetic engineering; complementarity zones. Patent number: US5693761. Assignee: Protein Design Labs, Inc.. Priority date: 28/12/1988. Publication date: 02/12/1997.

2. Socié G, Vigouroux S, Yakoub-Agha I, Bay JO, Fürst S, Bilger K, Suarez F, Michallet M, Bron D, Gard P et al.. (2017) A phase 3 randomized trial comparing inolimomab vs usual care in steroid-resistant acute GVHD. Blood129 (5): 643-649. [PMID:27899357]

How to cite this page

IL-2 receptor family: Interleukin-2 receptor subunit α. Last modified on 27/10/2017. Accessed on 18/01/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1695.