Interleukin-4 receptor subunit α

Target id: 1697

Nomenclature: Interleukin-4 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-4 receptor subunit α has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-4 receptor type I
Interleukin-4 receptor type II
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 800 16p12.1-p11.2 IL4R interleukin 4 receptor
Mouse 1 785 7 68.94 cM Il4ra interleukin 4 receptor, alpha
Rat 1 776 1q36 Il4r interleukin 4 receptor
Previous and Unofficial Names
CD124 | IL-4 receptor alpha chain | interleukin 4 receptor, alpha
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
dupilumab Hs Binding 11.1 pIC50 2
pIC50 11.1 (IC50 8.8x10-12 M) [2]
Description: Value derived from an ELISA-based solution competition assay.
Immunopharmacology Comments
IL4R is the common ligand binding subunit shared by the IL-4 receptors type I (receptor for IL-4) and type II (receptor for IL-4 and IL-13). A gain-of-function mutation in IL4R has been associated with atopy, enhanced B cell isotype switching from mu to epsilon and therefore elevated IgE levels [1]. This subunit is the molecular target of the investigational monoclonal antibody dupilumab, that is in clinical trial as a therapy for atopic allergic conditions and nasal polyposis.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-4 receptor activity (GO:0004913) TAS
positive regulation of chemokine secretion (GO:0090197) IEA
References: 
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  production of molecular mediator involved in inflammatory response (GO:0002532) IEA
positive regulation of macrophage activation (GO:0043032) IEA
positive regulation of mast cell degranulation (GO:0043306) IEA
negative regulation of T-helper 1 cell differentiation (GO:0045626) IEA
positive regulation of T-helper 2 cell differentiation (GO:0045630) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  immunoglobulin mediated immune response (GO:0016064) IEA
negative regulation of T-helper 1 cell differentiation (GO:0045626) IEA
positive regulation of T-helper 2 cell differentiation (GO:0045630) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  immunoglobulin mediated immune response (GO:0016064) IEA
negative regulation of T-helper 1 cell differentiation (GO:0045626) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of immunoglobulin production (GO:0002639) IEA
positive regulation of macrophage activation (GO:0043032) IEA
positive regulation of mast cell degranulation (GO:0043306) IEA
negative regulation of T-helper 1 cell differentiation (GO:0045626) IEA
positive regulation of T-helper 2 cell differentiation (GO:0045630) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of T-helper 1 cell differentiation (GO:0045626) IEA
positive regulation of T-helper 2 cell differentiation (GO:0045630) IEA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of T-helper 1 cell differentiation (GO:0045626) IEA
positive regulation of T-helper 2 cell differentiation (GO:0045630) IEA
positive regulation of chemokine secretion (GO:0090197) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of macrophage activation (GO:0043032) IEA
positive regulation of mast cell degranulation (GO:0043306) IEA
negative regulation of T-helper 1 cell differentiation (GO:0045626) IEA
positive regulation of T-helper 2 cell differentiation (GO:0045630) IEA
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Human immunodeficiency virus type 1, susceptibility to
Synonyms: Human immunodeficiency virus infectious disease [Disease Ontology: DOID:526]
Disease Ontology: DOID:526
OMIM: 609423
Orphanet: ORPHA319269
Role: 
References:  3
Disease:  IgE responsiveness, atopic; IGER
OMIM: 147050

References

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1. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. (1997) The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N. Engl. J. Med.337 (24): 1720-5. [PMID:9392697]

2. Martin JH, Huang TT, Fairhurst JL, Papadopoulos NJ. (2009) Cytokine specific immunoglobulin for use in diagnosis, prevention and treatment ,of cell proliferative, inflammatory, allergic, respiratory, autoimmune and arthritic disorders. Patent number: US7608693. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 02/10/2006. Publication date: 27/10/2009.

3. Soriano A, Lozano F, Oliva H, García F, Nomdedéu M, De Lazzari E, Rodríguez C, Barrasa A, Lorenzo JI, Del Romero J et al.. (2005) Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS. Immunogenetics57 (9): 644-54. [PMID:16189667]

How to cite this page

IL-2 receptor family: Interleukin-4 receptor subunit α. Last modified on 11/04/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1697.