Interleukin-7 receptor subunit α

Target id: 1698

Nomenclature: Interleukin-7 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-7 receptor subunit α has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-7 receptor
Thymic stromal lymphopoietin receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 459 05p13.2 IL7R interleukin 7 receptor
Mouse 1 459 Il7r interleukin 7 receptor
Rat - - Il7r interleukin 7 receptor
Previous and Unofficial Names
CD127 | interleukin-7 receptor subunit alpha | IL-7 receptor alpha chain
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

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Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
OSE-127 Hs Antagonist 11.4 pEC50 2
pEC50 11.4 (EC50 4x10-12 M) [2]
Description: In an ELISA binding assay.
Immunopharmacology Comments
This is the ligand binding subunit of the functional IL-7 receptor complex.
Immuno Cell Type Associations
Immuno Cell Type:  T cells
Cell Ontology Term:   effector T cell (CL:0000911)
Comment:  IL-7RA (CD127) is expressed on Teff cells, and is involved in the development and persistence of chronic colitis [4].
References:  1,3
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-7 receptor activity (GO:0004917) TAS
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of T cell mediated cytotoxicity (GO:0001915) IEA
T cell differentiation (GO:0030217) IEA
positive regulation of T cell differentiation in thymus (GO:0033089) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of T cell mediated cytotoxicity (GO:0001915) IEA
B cell proliferation (GO:0042100) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of T cell mediated cytotoxicity (GO:0001915) IEA
positive regulation of T cell differentiation in thymus (GO:0033089) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  T cell differentiation (GO:0030217) IEA
positive regulation of T cell differentiation in thymus (GO:0033089) IEA
lymph node development (GO:0048535) IEA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of T cell differentiation in thymus (GO:0033089) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  T cell differentiation (GO:0030217) IEA
positive regulation of T cell differentiation in thymus (GO:0033089) IEA
B cell proliferation (GO:0042100) IEA
References: 

References

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1. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B et al.. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med.203 (7): 1701-11. [PMID:16818678]

2. Poirier N, Mary C, Vanhove B. (2015) Antibodies directed against CD127. Patent number: WO2015189302. Assignee: Effimune. Priority date: 10/06/2014. Publication date: 17/12/2015.

3. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Alexander SI, Nanan R et al.. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med.203 (7): 1693-700. [PMID:16818676]

4. Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M. (2011) Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J. Immunol.186 (4): 2623-32. [PMID:21217010]

How to cite this page

IL-2 receptor family: Interleukin-7 receptor subunit α. Last modified on 19/07/2017. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1698.