<i>TAAR5</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

TAAR5

Target id: 170

Nomenclature: TAAR5

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for TAAR5 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 337 6q23 TAAR5 trace amine associated receptor 5 4
Mouse 7 337 10 A4 Taar5 trace amine-associated receptor 5
Rat 7 337 1p12 Taar5 trace amine-associated receptor 5
Previous and Unofficial Names
PNR | Trace amine receptor 5
Database Links
Specialist databases
GPCRDB taar5_human (Hs), taar5_mouse (Mm), taar5_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
trimethylamine Mm Full agonist 6.5 pEC50 2
pEC50 6.5 (EC50 3x10-7 M) [2]
dimethylethylamine Mm Full agonist 6.2 pEC50 5
pEC50 6.2 (EC50 7x10-7 M) [5]
Agonist Comments
It is reported that mTAAR5 responded to N-methylpiperidine [2]. Staubert et al. show that the agonists of murine TAAR5 do not activate intact primate and mammalian orthologs [3].
Tissue Distribution
Skeletal muscle, amydgala, hippocampus, caudate nucleus, thalamus, hypothalamus, substantia nigra.
Species:  Human
Technique:  Northern blot
References:  4
Grueneberg ganglion (nasal septum, nasal cavity and nasal roof)
Species:  Mouse
Technique:  RT-PCR and in situ hybridisation
References:  1
Olfactory epithelium
Species:  Mouse
Technique:  RT-PCR
References:  2
Tissue Distribution Comments
No transcripts of TAAR5 were detected by Northern blot analysis in corpus callosum, subthalamic nucleus, lung, heart, pancreas, adult liver, lymph node, bone marrow, thymus, placenta, spleen and fetal liver [4].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R330C
Global MAF (%):  2
Subpopulation MAF (%):  AFR|AMR: 10|1
Minor allele count:  A=0.024/52
SNP accession: 
Validation:  1000 Genomes, Frequency, Cluster
Type:  Naturally occurring SNP
Species:  Human
Amino acid change:  T272M
Comment on frequency:  Low frequency (<10% in tested population)
SNP accession: 

References

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1. Fleischer J, Schwarzenbacher K, Breer H. (2007) Expression of trace amine-associated receptors in the Grueneberg ganglion. Chem. Senses, 32 (6): 623-31. [PMID:17556730]

2. Liberles SD, Buck LB. (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature, 442: 645-650. [PMID:16878137]

3. Stäubert C, Böselt I, Bohnekamp J, Römpler H, Enard W, Schöneberg T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE, 5 (6): e11133. [PMID:20559446]

4. Zeng Z, Fan P, Rand E, Kyaw H, Su K, Madike V, Carter KC, Li Y. (1998) Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain. Biochem. Biophys. Res. Commun., 242 (3): 575-8. [PMID:9464258]

5. Zucchi R, Chiellini G, Scanlan TS, Grandy DK. (2006) Trace amine-associated receptors and their ligands. Br J Pharmacol, 149: 967-978. [PMID:17088868]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: TAAR5. Last modified on 30/06/2015. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=170.