Interleukin 13 receptor, α2

Target id: 1701

Nomenclature: Interleukin 13 receptor, α2

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin 13 receptor, α2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 380 Xq23 IL13RA2 interleukin 13 receptor subunit alpha 2
Mouse 1 383 Il13ra2 interleukin 13 receptor, alpha 2
Rat 1 385 Il13ra2 interleukin 13 receptor subunit alpha 2
Previous and Unofficial Names
cancer/testis antigen 19 | CD213a2 | CT19 | IL13BP | IL-13RA2 | IL-13 receptor alpha-2 | IL-13R subunit alpha-2
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
Interleukin 13 receptor, α2 acts as a high affinity decoy receptor for interleukin 13 that sequesters the ligand away from IL13Rα1 and is involved in down-regulating IL-13 responses in vivo. IL13ra2 null mice exhibit enhanced IL-13 responses [4].
Increased expression of IL13Rα2 has been reported to promote tumor progression in glioma and other tumor models, and its expression is a prognostic marker for glioma malignancy grade and for poor patient survival [1,3]. This receptor has not been detected on normal brian tissue, making IL13Rα2 a novel selective drug target that has been intensively investigated for the treatment of glioblastoma, with several immunotherapeutic candidates advancing to clinical trial (reviewed in [2]).
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  cytokine receptor activity (GO:0004896) TAS
References: 
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of mast cell degranulation (GO:0043305) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  immunoglobulin mediated immune response (GO:0016064) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  immunoglobulin mediated immune response (GO:0016064) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of immunoglobulin production (GO:0002638) IEA
negative regulation of mast cell degranulation (GO:0043305) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of mast cell degranulation (GO:0043305) IEA
References: 

References

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1. Debinski W, Gibo DM, Hulet SW, Connor JR, Gillespie GY. (1999) Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas. Clin. Cancer Res.5 (5): 985-90. [PMID:10353730]

2. Sengupta S, Thaci B, Crawford AC, Sampath P. (2014) Interleukin-13 receptor alpha 2-targeted glioblastoma immunotherapy. Biomed Res Int2014: 952128. [PMID:25247196]

3. Tu M, Wange W, Cai L, Zhu P, Gao Z, Zheng W. (2016) IL-13 receptor α2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway. Tumour Biol.37 (11): 14701-14709. [PMID:27623944]

4. Wood N, Whitters MJ, Jacobson BA, Witek J, Sypek JP, Kasaian M, Eppihimer MJ, Unger M, Tanaka T, Goldman SJ et al.. (2003) Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J. Exp. Med.197 (6): 703-9. [PMID:12642602]

How to cite this page

IL-2 receptor family: Interleukin 13 receptor, α2. Last modified on 10/04/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1701.