Cytokine receptor-like factor 2

Target id: 1704

Nomenclature: Cytokine receptor-like factor 2

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Cytokine receptor-like factor 2 has curated GtoImmuPdb data

Quaternary Structure: Complexes
Thymic stromal lymphopoietin receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 371 Xp22.3 and Yp11.3 CRLF2 cytokine receptor like factor 2
Mouse 1 359 Crlf2 cytokine receptor-like factor 2
Rat 1 360 Crlf2 cytokine receptor-like factor 2
Previous and Unofficial Names
thymic stromal lymphopoietin protein receptor | Tpte2 | TSLP receptor | Ly114 | CRL2 | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
Cytokine receptor-like factor 2 is the signal transducing subunit of the functional heterodimeric receptor for thymic stromal lymphopoietin (TSLP). Ligand binding is attributed to the interleukin-7 receptor subunit α.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0033005 positive regulation of mast cell activation IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0033005 positive regulation of mast cell activation IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0004896 cytokine receptor activity IDA
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0038111 interleukin-7-mediated signaling pathway TAS
GO:2000664 positive regulation of interleukin-5 secretion IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0004896 cytokine receptor activity IDA
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0038111 interleukin-7-mediated signaling pathway TAS
GO:2000664 positive regulation of interleukin-5 secretion IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0004896 cytokine receptor activity IDA
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0038111 interleukin-7-mediated signaling pathway TAS
GO:2000664 positive regulation of interleukin-5 secretion IMP
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0033005 positive regulation of mast cell activation IMP

How to cite this page

IL-2 receptor family: Cytokine receptor-like factor 2. Last modified on 10/04/2017. Accessed on 20/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1704.