Interleukin 5 receptor, α subunit

Target id: 1706

Nomenclature: Interleukin 5 receptor, α subunit

Family: IL-3 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin 5 receptor, α subunit has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-5 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 420 03p26.2 IL5RA interleukin 5 receptor subunit alpha
Mouse 1 415 Il5ra interleukin 5 receptor
Rat - - Il5ra interleukin 5 receptor subunit alpha
Previous and Unofficial Names
CD125 | interleukin-5 receptor subunit alpha
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

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Agonists
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Ligand Sp. Action Affinity Units Reference
IL-5 {Sp: Human} Hs Agonist - -
Antibodies
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Antibody Sp. Action Affinity Units Reference
benralizumab Hs Binding 8.7 pKd 1
pKd 8.7 (Kd 2.13x10-9 M) [1]
Immunopharmacology Comments
This is the ligand binding subunit of the functional IL-5 receptor complex.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-5 receptor activity (GO:0004914) TAS
regulation of interleukin-5 production (GO:0032674) IEA
References: 
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  inflammatory response to antigenic stimulus (GO:0002437) IEA
References: 

References

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1. Koike M, Spitalny GL, Wheeler A, White B. (2013) Methods of reducing eosinophil levels. Patent number: US8501176. Assignee: Medimmune, Llc, Biowa, Inc.. Priority date: 14/05/2007. Publication date: 06/08/2013.

How to cite this page

IL-3 receptor family: Interleukin 5 receptor, α subunit. Last modified on 22/03/2017. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1706.