Quaternary Structure: Complexes

Interleukin-31 receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	732	5q11.2	IL31RA	interleukin 31 receptor A
Mouse	1	716	13 D2.2	Il31ra	interleukin 31 receptor A
Rat	-	718	2q14	Il31ra	interleukin 31 receptor A

Previous and Unofficial Names

CRL | CRL3 | interleukin-31 receptor subunit alpha | GPL | Glmr | NR10 [1]

Database Links
Alphafold	Q8NI17 (Hs), Q8K5B1 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL4630894 (Hs)
Ensembl Gene	ENSG00000164509 (Hs), ENSMUSG00000050377 (Mm), ENSRNOG00000042080 (Rn)
Entrez Gene	133396 (Hs), 218624 (Mm), 688622 (Rn)
Human Protein Atlas	ENSG00000164509 (Hs)
KEGG Gene	hsa:133396 (Hs), mmu:218624 (Mm), rno:688622 (Rn)
OMIM	609510 (Hs)
Pharos	Q8NI17 (Hs)
RefSeq Nucleotide	NM_001242636 (Hs), NM_139299 (Mm), NM_001257278 (Rn)
RefSeq Protein	NP_001229565 (Hs), NP_647460 (Mm), NP_001244207 (Rn)
UniProtKB	Q8NI17 (Hs), Q8K5B1 (Mm)
Wikipedia	IL31RA (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference nemolizumab Hs Binding 8.7 pKd 1 ⤷ pKd 8.7 (Kd 2x10-9 M) [1]

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Immuno Process:  T cell (activation)

Immuno Process:  B cell (activation)

General Comments
The IL-31 receptor subunit α functions a monomer and as part of a receptor complex with the oncostatin M receptor (OSMR). It is a type I cytokine receptor that is involved in IL-31 signalling which is mediated via activation of STAT3 and STAT5.