Interleukin-31 receptor, α subunit

Target id: 1710

Nomenclature: Interleukin-31 receptor, α subunit

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-31 receptor, α subunit has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-31 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 745 5q11.2 IL31RA interleukin 31 receptor A
Mouse 1 716 13 D2.2 Il31ra interleukin 31 receptor A
Rat - 718 2q14 Il31ra interleukin 31 receptor A
Previous and Unofficial Names
CRL | CRL3 | interleukin-31 receptor subunit alpha | GPL | Glmr | NR10 [1]
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
nemolizumab Hs Binding 8.7 pKd 1
pKd 8.7 (Kd 2x10-9 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0043031 negative regulation of macrophage activation NAS
click arrow to show/hide IEA associations
GO:0002438 acute inflammatory response to antigenic stimulus IEA
GO:0035745 T-helper 2 cell cytokine production IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0043031 negative regulation of macrophage activation NAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0030224 monocyte differentiation IEP
GO:0030225 macrophage differentiation NAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0004896 cytokine receptor activity TAS
GO:0019221 cytokine-mediated signaling pathway TAS
click arrow to show/hide IEA associations
GO:0035745 T-helper 2 cell cytokine production IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043031 negative regulation of macrophage activation NAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0035745 T-helper 2 cell cytokine production IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0035745 T-helper 2 cell cytokine production IEA

References

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1. Kuramochi T, Kasutani K, Ohyama S, Tsunoda H, Igawa T, Tachibana T, Shiraiwa H, Esaki K. (2013) Anti-NR10 antibody and use thereof. Patent number: US8575317 B2. Assignee: Chugai Seiyaku Kabushiki Kaisha. Priority date: 05/12/2007. Publication date: 05/11/2013.

How to cite this page

IL-6 receptor family: Interleukin-31 receptor, α subunit. Last modified on 05/10/2016. Accessed on 23/04/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1710.