IL-6 receptor family | Catalytic receptors | IUPHAR/BPS Guide to PHARMACOLOGY

IL-6 receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The IL-6 receptor family signal through a ternary receptor complex consisting of the cognate receptor and either the IL-6 signal transducer gp130 (IL6ST, P40189) or the oncostatin M-specific receptor, β subunit (OSMR, Q99650), which then activates the JAK/STAT, Ras/Raf/MAPK and PI 3-kinase/PKB signalling modules. Unusually amongst the cytokine receptors, the CNTF receptor is a glycerophosphatidylinositol-linked protein.

Receptors

1712

Complexes

Interleukin-6 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2310

Nomenclature

Interleukin-6 receptor

Subunits

Interleukin-6 receptor, α subunit (Ligand-binding subunit)
Interleukin-6 receptor, β subunit (Other subunit)

Endogenous agonists

IL-6 (IL6, P05231) (Murine NIH/3T3 fibroblasts with human IL6R exhibited a single class of binding sites for 125I-labeled recombinant human interleukin-6 (125I-rhIL-6) (Kd = 440 pM, 20,000 receptors per cell).) [4]

Antibodies

vobarilizumab (Binding) pK_d 12.7 [6]

satralizumab (Binding) pK_d 8.9 [2]

tocilizumab (Binding) pK_d 8.6

Interleukin-11 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-27 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-31 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Ciliary neutrophic factor receptor C Show summary »« Hide summary

Leukemia inhibitory factor receptor C Show summary »« Hide summary

Oncostatin-M receptor C Show summary »« Hide summary More detailed page go icon to follow link

Receptors and Subunits

IL6R (Interleukin-6 receptor, α subunit / interleukin 6 receptor) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1708

Nomenclature

Interleukin-6 receptor, α subunit

Systematic nomenclature

interleukin 6 receptor

Common abbreviation

IL6R

Previous and unofficial names

CD126 | IL-6R subunit alpha | interleukin 6 receptor

Complexes

Interleukin-6 receptor

Genes

IL6R (Hs), Il6ra (Mm), Il6r (Rn)

Ensembl ID

ENSG00000160712 (Hs), ENSMUSG00000027947 (Mm), ENSRNOG00000020811 (Rn)

UniProtKB AC

P08887 (Hs), P22272 (Mm), P22273 (Rn)

Endogenous agonists

IL-6 (IL6, P05231) (Selective) (IL6R) expressed stably in murine NIH/3T3 fibroblasts.exhibited a single class of binding sites for 125I-labeled recombinant human interleukin-6 (125I-rhIL-6) (Kd = 440 pM, 20,000 receptors per cell).) [4]

Antibodies

sarilumab (Binding) pK_d 10.6 – 11.1 [5]

IL6ST (Interleukin-6 receptor, β subunit / interleukin 6 signal transducer) C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-11 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 27 receptor, alpha C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-31 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Ciliary neurotrophic factor receptor α subunit C Show summary »« Hide summary

Leptin receptor C Show summary »« Hide summary

Target Id

1712

Nomenclature

Leptin receptor

Previous and unofficial names

CD295 | OB receptor | Modb1 | OBR

Genes

LEPR (Hs), Lepr (Mm), Lepr (Rn)

Ensembl ID

ENSG00000116678 (Hs), ENSMUSG00000057722 (Mm), ENSRNOG00000023664 (Rn)

UniProtKB AC

P48357 (Hs), P48356 (Mm), Q62959 (Rn)

Endogenous agonists

leptin (LEP, P41159) [7] - Mouse

Leukemia inhibitory factor receptor C Show summary »« Hide summary

Oncostatin M-specific receptor, β subunit C Show summary »« Hide summary More detailed page go icon to follow link

References

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1. Berl T, Schwertschlag U. (2000) Preclinical pharmacologic basis for clinical use of rhIL-11 as an effective platelet-support agent. Oncology (Williston Park, NY), 14 (9 Suppl 8): 12-20. [PMID:11033834]

2. Igawa T, Ishii S, Maeda A, Sakurai M, Kojima T, Tachibana T, Shiraiwa H, Tsunoda H, Higuchi Y. (2013) Antibody molecules that bind to IL-6 receptor. Patent number: US8562991 B2. Assignee: Chugai Seiyaku Kabushiki Kaisha. Priority date: 26/09/2008. Publication date: 22/10/2013.

3. Kuramochi T, Kasutani K, Ohyama S, Tsunoda H, Igawa T, Tachibana T, Shiraiwa H, Esaki K. (2013) Anti-NR10 antibody and use thereof. Patent number: US8575317 B2. Assignee: Chugai Seiyaku Kabushiki Kaisha. Priority date: 05/12/2007. Publication date: 05/11/2013.

4. Rose-John S, Hipp E, Lenz D, Legrés LG, Korr H, Hirano T, Kishimoto T, Heinrich PC. (1991) Structural and functional studies on the human interleukin-6 receptor. Binding, cross-linking, internalization, and degradation of interleukin-6 by fibroblasts transfected with human interleukin-6-receptor cDNA. J Biol Chem, 266 (6): 3841-6. [PMID:1995637]

5. Stevens S, Huang TT, Martin JH, Fairhurst JL, Rafique A, Smith E, Pobursky KJ, Papadopoulos NJ, Fandl JP, Chen G et al.. (2009) High affinity antibodies to human IL-6 receptor. Patent number: US7582298. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 02/06/2006. Publication date: 01/09/2009.

6. Van Roy M, Ververken C, Beirnaert E, Hoefman S, Kolkman J, Vierboom M, Breedveld E, 't Hart B, Poelmans S, Bontinck L et al.. (2015) The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis. Arthritis Res Ther, 17: 135. [PMID:25994180]

7. Verkerke H, Naylor C, Zabeau L, Tavernier J, Petri Jr WA, Marie C. (2014) Kinetics of leptin binding to the Q223R leptin receptor. PLoS ONE, 9 (4): e94843. [PMID:24743494]

8. Wilde MI, Faulds D. (1998) Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs, 10 (2): 159-71. [PMID:18020592]

How to cite this family page

Database page citation:

IL-6 receptor family. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=307.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.