IL-6 receptor family | Catalytic receptors | IUPHAR/BPS Guide to PHARMACOLOGY

IL-6 receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The IL-6 receptor family signal through a ternary receptor complex consisting of the cognate receptor and either the IL-6 signal transducer gp130 (IL6ST, P40189) or the oncostatin M-specific receptor, β subunit (OSMR, Q99650), which then activates the JAK/STAT, Ras/Raf/MAPK and PI 3-kinase/PKB signalling modules. Unusually amongst the cytokine receptors, the CNTF receptor is a glycerophosphatidylinositol-linked protein.

Receptors

1713

Complexes

Interleukin-6 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2310

Nomenclature

Interleukin-6 receptor

Subunits

Interleukin-6 receptor, α subunit (Ligand-binding subunit)
Interleukin-6 receptor, β subunit (Other subunit)

Endogenous agonists

IL-6 (IL6, P05231) (Murine NIH/3T3 fibroblasts with human IL6R exhibited a single class of binding sites for 125I-labeled recombinant human interleukin-6 (125I-rhIL-6) (Kd = 440 pM, 20,000 receptors per cell).) [4]

Antibodies

vobarilizumab (Binding) pK_d 12.7 [6]

satralizumab (Binding) pK_d 8.9 [2]

tocilizumab (Binding) pK_d 8.6

Interleukin-11 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-27 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-31 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Ciliary neutrophic factor receptor C Show summary »« Hide summary

Leukemia inhibitory factor receptor C Show summary »« Hide summary

Oncostatin-M receptor C Show summary »« Hide summary More detailed page go icon to follow link

Receptors and Subunits

IL6R (Interleukin-6 receptor, α subunit / interleukin 6 receptor) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1708

Nomenclature

Interleukin-6 receptor, α subunit

Systematic nomenclature

interleukin 6 receptor

Common abbreviation

IL6R

Previous and unofficial names

CD126 | IL-6R subunit alpha | interleukin 6 receptor

Complexes

Interleukin-6 receptor

Genes

IL6R (Hs), Il6ra (Mm), Il6r (Rn)

Ensembl ID

ENSG00000160712 (Hs), ENSMUSG00000027947 (Mm), ENSRNOG00000020811 (Rn)

UniProtKB AC

P08887 (Hs), P22272 (Mm), P22273 (Rn)

Endogenous agonists

IL-6 (IL6, P05231) (Selective) (IL6R) expressed stably in murine NIH/3T3 fibroblasts.exhibited a single class of binding sites for 125I-labeled recombinant human interleukin-6 (125I-rhIL-6) (Kd = 440 pM, 20,000 receptors per cell).) [4]

Antibodies

sarilumab (Binding) pK_d 10.6 – 11.1 [5]

IL6ST (Interleukin-6 receptor, β subunit / interleukin 6 signal transducer) C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-11 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin 27 receptor, alpha C Show summary »« Hide summary More detailed page go icon to follow link

Interleukin-31 receptor, α subunit C Show summary »« Hide summary More detailed page go icon to follow link

Ciliary neurotrophic factor receptor α subunit C Show summary »« Hide summary

Leptin receptor C Show summary »« Hide summary

Leukemia inhibitory factor receptor C Show summary »« Hide summary

Target Id	1713
Nomenclature	Leukemia inhibitory factor receptor
Previous and unofficial names	CD118 \| LIF receptor \| soluble differentiation-stimulating factor receptor \| Leukemia inhibitory factor receptor α \| leukemia inhibitory factor receptor alpha \| LIF receptor alpha
Complexes	Ciliary neutrophic factor receptor Leukemia inhibitory factor receptor
Genes	LIFR (Hs), Lifr (Mm), Lifr (Rn)
Ensembl ID	ENSG00000113594 (Hs), ENSMUSG00000054263 (Mm), ENSRNOG00000011696 (Rn)
UniProtKB AC	P42702 (Hs), P42703 (Mm), O70535 (Rn)

Oncostatin M-specific receptor, β subunit C Show summary »« Hide summary More detailed page go icon to follow link

References

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1. Berl T, Schwertschlag U. (2000) Preclinical pharmacologic basis for clinical use of rhIL-11 as an effective platelet-support agent. Oncology (Williston Park, NY), 14 (9 Suppl 8): 12-20. [PMID:11033834]

2. Igawa T, Ishii S, Maeda A, Sakurai M, Kojima T, Tachibana T, Shiraiwa H, Tsunoda H, Higuchi Y. (2013) Antibody molecules that bind to IL-6 receptor. Patent number: US8562991 B2. Assignee: Chugai Seiyaku Kabushiki Kaisha. Priority date: 26/09/2008. Publication date: 22/10/2013.

3. Kuramochi T, Kasutani K, Ohyama S, Tsunoda H, Igawa T, Tachibana T, Shiraiwa H, Esaki K. (2013) Anti-NR10 antibody and use thereof. Patent number: US8575317 B2. Assignee: Chugai Seiyaku Kabushiki Kaisha. Priority date: 05/12/2007. Publication date: 05/11/2013.

4. Rose-John S, Hipp E, Lenz D, Legrés LG, Korr H, Hirano T, Kishimoto T, Heinrich PC. (1991) Structural and functional studies on the human interleukin-6 receptor. Binding, cross-linking, internalization, and degradation of interleukin-6 by fibroblasts transfected with human interleukin-6-receptor cDNA. J Biol Chem, 266 (6): 3841-6. [PMID:1995637]

5. Stevens S, Huang TT, Martin JH, Fairhurst JL, Rafique A, Smith E, Pobursky KJ, Papadopoulos NJ, Fandl JP, Chen G et al.. (2009) High affinity antibodies to human IL-6 receptor. Patent number: US7582298. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 02/06/2006. Publication date: 01/09/2009.

6. Van Roy M, Ververken C, Beirnaert E, Hoefman S, Kolkman J, Vierboom M, Breedveld E, 't Hart B, Poelmans S, Bontinck L et al.. (2015) The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis. Arthritis Res Ther, 17: 135. [PMID:25994180]

7. Verkerke H, Naylor C, Zabeau L, Tavernier J, Petri Jr WA, Marie C. (2014) Kinetics of leptin binding to the Q223R leptin receptor. PLoS ONE, 9 (4): e94843. [PMID:24743494]

8. Wilde MI, Faulds D. (1998) Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs, 10 (2): 159-71. [PMID:18020592]

How to cite this family page

Database page citation:

IL-6 receptor family. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=307.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.