Interleukin-12 receptor, β1 subunit

Target id: 1715

Nomenclature: Interleukin-12 receptor, β1 subunit

Family: IL-12 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-12 receptor, β1 subunit has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-12 receptor
Interleukin-23 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 662 19p13.11 IL12RB1 interleukin 12 receptor subunit beta 1
Mouse 1 738 Il12rb1 interleukin 12 receptor, beta 1
Rat - - Il12rb1 interleukin 12 receptor subunit beta 1
Previous and Unofficial Names
CD212 | interleukin 12 receptor, beta 1
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
This protein is a subunit of both the IL-12 and IL-23 cytokine receptors.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of memory T cell differentiation (GO:0043382) ISS
cellular response to interferon-gamma (GO:0071346) IDA
positive regulation of T-helper 17 cell lineage commitment (GO:2000330) ISS
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell mediated cytotoxicity (GO:0001916) ISS
positive regulation of T-helper 1 type immune response (GO:0002827) IDA
positive regulation of activated T cell proliferation (GO:0042104) IDA
positive regulation of memory T cell differentiation (GO:0043382) ISS
positive regulation of T-helper 17 type immune response (GO:2000318) ISS
positive regulation of T-helper 17 cell lineage commitment (GO:2000330) ISS
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell mediated cytotoxicity (GO:0001916) ISS
positive regulation of T-helper 1 type immune response (GO:0002827) IDA
positive regulation of T-helper 17 type immune response (GO:2000318) ISS
positive regulation of T-helper 17 cell lineage commitment (GO:2000330) ISS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of T cell mediated cytotoxicity (GO:0001916) ISS
positive regulation of defense response to virus by host (GO:0002230) IDA
positive regulation of T-helper 1 type immune response (GO:0002827) IDA
positive regulation of activated T cell proliferation (GO:0042104) IDA
positive regulation of memory T cell differentiation (GO:0043382) ISS
positive regulation of T-helper 17 type immune response (GO:2000318) ISS
positive regulation of T-helper 17 cell lineage commitment (GO:2000330) ISS
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of memory T cell differentiation (GO:0043382) ISS
positive regulation of T-helper 17 cell lineage commitment (GO:2000330) ISS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  cytokine receptor activity (GO:0004896) TAS
cytokine-mediated signaling pathway (GO:0019221) TAS
positive regulation of interferon-gamma production (GO:0032729) IDA
interleukin-12-mediated signaling pathway (GO:0035722) IEA
interleukin-23-mediated signaling pathway (GO:0038155) IEA
cellular response to interferon-gamma (GO:0071346) IDA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of activated T cell proliferation (GO:0042104) IDA
positive regulation of memory T cell differentiation (GO:0043382) ISS
positive regulation of T-helper 17 cell lineage commitment (GO:2000330) ISS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of activated T cell proliferation (GO:0042104) IDA
positive regulation of memory T cell differentiation (GO:0043382) ISS
positive regulation of T-helper 17 cell lineage commitment (GO:2000330) ISS
References: 

How to cite this page

IL-12 receptor family: Interleukin-12 receptor, β1 subunit. Last modified on 22/03/2017. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1715.