Granulocyte colony-stimulating factor receptor

Target id: 1719

Nomenclature: Granulocyte colony-stimulating factor receptor

Family: Prolactin receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Granulocyte colony-stimulating factor receptor has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 836 1p35-p34.3 CSF3R colony stimulating factor 3 receptor
Mouse 1 837 4 59.77 cM Csf3r colony stimulating factor 3 receptor (granulocyte)
Rat - - 5q36 Csf3r colony stimulating factor 3 receptor
Previous and Unofficial Names
CD114 | granulocyte colony-stimulating factor receptor | GCSFR
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal Structure of the human GCSF-receptor signaling complex
PDB Id:  2D9Q
Resolution:  2.8Å
Species:  Human
References:  3

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
G-CSF {Sp: Human} Hs Agonist - -
pegfilgrastim Hs Agonist - -
Agonist Comments
The granulocyte colony-stimulating factor receptor (CSF3R) is the primary target for the approved drugs filgrastim and pegfilgrastim.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  neutrophil chemotaxis (GO:0030593) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of myeloid cell differentiation (GO:0045637) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of myeloid cell differentiation (GO:0045637) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  cytokine receptor activity (GO:0004896) IEA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  neutrophil chemotaxis (GO:0030593) IEA
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Atypical chronic myeloid leukemia
Orphanet: ORPHA98824
References:  2
Disease:  Chronic neutrophilic leukemia
Orphanet: ORPHA86829
References:  1-2
Disease:  Neutrophilia, hereditary
OMIM: 162830
Orphanet: ORPHA279943

References

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1. Lasho TL, Mims A, Elliott MA, Finke C, Pardanani A, Tefferi A. (2014) Chronic neutrophilic leukemia with concurrent CSF3R and SETBP1 mutations: single colony clonality studies, in vitro sensitivity to JAK inhibitors and lack of treatment response to ruxolitinib. Leukemia,  [Epub ahead of print]. [PMID:24445868]

2. Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE et al.. (2013) Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N. Engl. J. Med.368 (19): 1781-90. [PMID:23656643]

3. Tamada T, Honjo E, Maeda Y, Okamoto T, Ishibashi M, Tokunaga M, Kuroki R. (2006) Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex. Proc. Natl. Acad. Sci. U.S.A.103 (9): 3135-40. [PMID:16492764]

How to cite this page

Prolactin receptor family: Granulocyte colony-stimulating factor receptor. Last modified on 05/10/2016. Accessed on 12/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719.