Growth hormone receptor

Target id: 1720

Nomenclature: Growth hormone receptor

Family: Prolactin receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Growth hormone receptor in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 638 5p14-p12 GHR growth hormone receptor
Mouse 1 650 15 1.84 cM Ghr growth hormone receptor
Rat 1 638 2q16 Ghr growth hormone receptor
Previous and Unofficial Names
GH-binding protein | GHBP | GH receptor | somatotropin receptor
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Human growth hormone bound to the growth hormone receptor
PDB Id:  1A22
Ligand:  growth hormone 1
Resolution:  2.6Å
Species:  Human
References:  1

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
growth hormone 1 {Sp: Human} Hs Agonist - -
growth hormone 2 {Sp: Human} Hs Agonist - -
Antagonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
pegvisomant Hs Antagonist - - 2
[2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Growth hormone insensitivity, partial; GHIP
Synonyms: Short stature due to partial GHR deficiency [Orphanet: ORPHA314802]
OMIM: 604271
Orphanet: ORPHA314802
Disease:  Hypercholesterolemia, familial
Disease Ontology: DOID:13810
OMIM: 143890
Disease:  Laron syndrome
Disease Ontology: DOID:9521
OMIM: 262500
Orphanet: ORPHA633

References

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1. Clackson T, Ultsch MH, Wells JA, de Vos AM. (1998) Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. J. Mol. Biol.277 (5): 1111-28. [PMID:9571026]

2. Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, Dimaraki EV, Stewart PM, Friend KE, Vance ML et al.. (2000) Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N. Engl. J. Med.342 (16): 1171-7. [PMID:10770982]

How to cite this page

Prolactin receptor family: Growth hormone receptor. Last modified on 23/01/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1720.