Thrombopoietin receptor

Target id: 1722

Nomenclature: Thrombopoietin receptor

Family: Prolactin receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 635 1p34 MPL MPL proto-oncogene, thrombopoietin receptor
Mouse - 625 4 54.61 cM Mpl myeloproliferative leukemia virus oncogene
Rat - - 5q36 Mpl MPL proto-oncogene, thrombopoietin receptor
Previous and Unofficial Names
CD110
MPL
Myeloproliferative leukemia protein
TPOR
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Gene
NeXtProt
OMIM
Orphanet
PhosphoSitePlus
TreeFam
UniProtKB
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
romiplostim Hs Agonist - -
eltrombopag Hs Agonist - -
thrombopoietin {Sp: Human} Hs Agonist - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Congenital amegakaryocytic thrombocytopenia
OMIM: 604498
Orphanet: ORPHA3319
Disease:  Familial thrombocytosis
Synonyms: Hereditary thrombocythemia
Orphanet: ORPHA71493
Disease:  Myelofibrosis
Synonyms: Myelofibrosis with myeloid metaplasia [Orphanet: ORPHA824]
Disease Ontology: DOID:4971
OMIM: 254450
Orphanet: ORPHA824
Disease:  Polycythemia vera
Disease Ontology: DOID:8997
OMIM: 263300
Orphanet: ORPHA729
Disease:  Thrombocythemia 2
Synonyms: Essential thrombocythemia [Orphanet: ORPHA3318]
Essential thrombocytosis [Orphanet: ORPHA3318]
OMIM: 601977
Orphanet: ORPHA3318

How to cite this page

Prolactin receptor family: Thrombopoietin receptor. Last modified on 26/02/2015. Accessed on 05/05/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722.