Thrombopoietin receptor

Nomenclature: Thrombopoietin receptor

Family: Cytokine receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 635 1p34 MPL myeloproliferative leukemia virus oncogene
Mouse - 625 4 54.61 cM Mpl myeloproliferative leukemia virus oncogene
Rat - - 5q36 Mpl myeloproliferative leukemia virus oncogene
Previous and Unofficial Names
Myeloproliferative leukemia protein
C-mpl
CD110
MPL
TPOR
LOC366455
Mpl_predicted
myeloproliferative leukemia virus oncogene
myeloproliferative leukemia virus oncogene (predicted)
thrombopoietin receptor
TPO-R
c-mpl-I
c-mpl-II
hlb219
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Gene
OMIM
Orphanet Gene
PhosphoSitePlus
TreeFam
UniProtKB
Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
romiplostim Hs Agonist - -
eltrombopag Hs Agonist - -
thrombopoietin {Sp: Human} Hs Agonist - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Thrombocythemia 2
OMIM:  601977
Orphanet:  3318
References: 
Mutations not determined
Disease:  Myelofibrosis with myeloid metaplasia
OMIM:  254450
Orphanet:  824
References: 
Mutations not determined
Disease:  Congential amegakaryocytic thrombocytopenia
OMIM:  604498
Orphanet:  3319
References: 
Mutations not determined
Disease:  Familial thrombocytosis
Orphanet:  71493
References: 
Mutations not determined
Disease:  Polycythemia vera
Orphanet:  729
References: 
Mutations not determined

How to cite this page

Cytokine receptor family: Thrombopoietin receptor. Last modified on 11/03/2014. Accessed on 18/04/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722.