interferon α/β receptor 1

Target id: 1723

Nomenclature: interferon α/β receptor 1

Family: Interferon receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     interferon α/β receptor 1 has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interferon-α/β receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 557 21q22.11 IFNAR1 interferon alpha and beta receptor subunit 1
Mouse 1 590 Ifnar1 interferon (alpha and beta) receptor 1
Rat - - Ifnar1 interferon alpha and beta receptor subunit 1
Previous and Unofficial Names
IFRC | interferon (alpha and beta) receptor 1 | interferon (alpha, beta and omega) receptor 1 | Ifar | IFN-alpha/betaR
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
peginterferon alfa-2b Hs Agonist - - 2
[2]
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
anifrolumab Hs Binding >10.0 pKd 1
pKd >10.0 (Kd <1x10-10 M) [1]
Immunopharmacology Comments
A subunit of the functional receptor for various interferons (NOT interferon γ).
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  type I interferon receptor activity (GO:0004905) IDA
type I interferon signaling pathway (GO:0060337) IDA
regulation of type I interferon-mediated signaling pathway (GO:0060338) TAS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  regulation of type I interferon-mediated signaling pathway (GO:0060338) TAS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  type I interferon receptor activity (GO:0004905) IDA
interleukin-10 receptor activity (GO:0004920) IBA
positive regulation of interferon-beta production (GO:0032728) IEA
positive regulation of interferon-gamma production (GO:0032729) IEA
cellular response to interferon-alpha (GO:0035457) ISS
type I interferon biosynthetic process (GO:0045351) IEA
positive regulation of interleukin-1 beta secretion (GO:0050718) IEA
type I interferon signaling pathway (GO:0060337) IDA
regulation of type I interferon-mediated signaling pathway (GO:0060338) TAS
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  T cell activation (GO:0042110) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  T cell activation (GO:0042110) IEA
References: 

References

Show »

1. Cardarelli JM, Witte A, Srinivasan M. (2010) Interferon alpha receptor I antibodies and their use. Patent number: US7662381. Assignee: Medarex, Inc.. Priority date: 21/06/2004. Publication date: 16/02/2010.

2. Ward AC, Touw I, Yoshimura A. (2000) The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood95 (1): 19-29. [PMID:10607680]

How to cite this page

Interferon receptor family: interferon α/β receptor 1. Last modified on 10/04/2017. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1723.