interferon α/β receptor 1

Target id: 1723

Nomenclature: interferon α/β receptor 1

Family: Interferon receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     interferon α/β receptor 1 has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interferon-α/β receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 557 21q22.11 IFNAR1 interferon alpha and beta receptor subunit 1
Mouse 1 590 Ifnar1 interferon (alpha and beta) receptor 1
Rat - - Ifnar1 interferon alpha and beta receptor subunit 1
Previous and Unofficial Names
IFRC | interferon (alpha and beta) receptor 1 | interferon (alpha, beta and omega) receptor 1 | Ifar | IFN-alpha/betaR
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
IFN-β {Sp: Human} Hs Agonist 7.8 pKd 5
pKd 7.8 (Kd 1.58x10-8 M) [5]
Description: Measured using a surface plasmon resonance (SPR) assay, and recombinant hIFNAR1-extracellular domain (ECD) expressed in insect cells.
peginterferon alfa-2b Hs Agonist - - 4
[4]
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
anifrolumab Hs Binding >10.0 pKd 1
pKd >10.0 (Kd <1x10-10 M) [1]
Immunopharmacology Comments
IFNAR1 is a subunit of the functional receptor for type I interferons (NOT interferon γ). Type I interferons (IFN) exhibit an established anti-viral action. However, type I IFN signalling also appears to play a role in impaired resistance to a range of other pathogens (e.g. bacterial infection) [2-3]. A rare mutation in IFNAR1, identified in the Chinese population, that impairs type I IFN signalling, is associated with increased resistance to tuberculosis infection and reduced TB symptoms [5].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0004905 type I interferon receptor activity IDA
GO:0060337 type I interferon signaling pathway IDA
GO:0060338 regulation of type I interferon-mediated signaling pathway TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0060338 regulation of type I interferon-mediated signaling pathway TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 9 GO processes
GO:0004905 type I interferon receptor activity IDA
GO:0004920 interleukin-10 receptor activity IBA
GO:0035457 cellular response to interferon-alpha ISS
GO:0060337 type I interferon signaling pathway IDA
GO:0060338 regulation of type I interferon-mediated signaling pathway TAS
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GO:0032728 positive regulation of interferon-beta production IEA
GO:0032729 positive regulation of interferon-gamma production IEA
GO:0045351 type I interferon biosynthetic process IEA
GO:0050718 positive regulation of interleukin-1 beta secretion IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0042110 T cell activation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0042110 T cell activation IEA
Biologically Significant Variants
Type:  Insertion/deletion
Species:  Human
Description:  An in-frame deletion of a nucleotide codon that corresponds to a proline deletion in IFNAR1, reduces type I interferon binding affinity and increases resistance to tuberculosis infection and reduces TB pathology.
Amino acid change:  Pro335del
Nucleotide change:  TCCdel
SNP accession: 
References:  5

References

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1. Cardarelli JM, Witte A, Srinivasan M. (2010) Interferon alpha receptor I antibodies and their use. Patent number: US7662381. Assignee: Medarex, Inc.. Priority date: 21/06/2004. Publication date: 16/02/2010.

2. Carrero JA. (2013) Confounding roles for type I interferons during bacterial and viral pathogenesis. Int. Immunol., 25 (12): 663-9. [PMID:24158954]

3. Ng CT, Mendoza JL, Garcia KC, Oldstone MB. (2016) Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes. Cell, 164 (3): 349-52. [PMID:26824652]

4. Ward AC, Touw I, Yoshimura A. (2000) The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood, 95 (1): 19-29. [PMID:10607680]

5. Zhang G, deWeerd NA, Stifter SA, Liu L, Zhou B, Wang W, Zhou Y, Ying B, Hu X, Matthews AY et al.. (2018) A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans. Nat Commun, 9 (1): 85. [PMID:29311663]

How to cite this page

Interferon receptor family: interferon α/β receptor 1. Last modified on 18/01/2018. Accessed on 21/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1723.