Quaternary Structure: Complexes

Interferon-α/β receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	557	21q22.11	IFNAR1	interferon alpha and beta receptor subunit 1
Mouse	1	590	16 52.98 cM	Ifnar1	interferon (alpha and beta) receptor 1
Rat	-	-		Ifnar1	interferon alpha and beta receptor subunit 1

Previous and Unofficial Names

IFRC | interferon (alpha and beta) receptor 1 | interferon (alpha, beta and omega) receptor 1 | Ifar | IFN-alpha/betaR

Database Links
Alphafold	P17181 (Hs), P33896 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL1887 (Hs)
DrugBank Target	P17181 (Hs)
Ensembl Gene	ENSG00000142166 (Hs), ENSMUSG00000022967 (Mm), ENSRNOG00000028594 (Rn)
Entrez Gene	3454 (Hs), 15975 (Mm), 288264 (Rn)
Human Protein Atlas	ENSG00000142166 (Hs)
KEGG Gene	hsa:3454 (Hs), mmu:15975 (Mm), rno:288264 (Rn)
OMIM	107450 (Hs)
Pharos	P17181 (Hs)
UniProtKB	P17181 (Hs), P33896 (Mm)
Wikipedia	IFNAR1 (Hs)

Natural/Endogenous Ligands
IFN-β {Sp: Human}

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Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference IFN-β {Sp: Human} Hs Agonist 7.8 pKd 5 ⤷ pKd 7.8 (Kd 1.58x10-8 M) [5] Description: Measured using a surface plasmon resonance (SPR) assay, and recombinant hIFNAR1-extracellular domain (ECD) expressed in insect cells. peginterferon alfa-2b Hs Agonist - - 4 ⤷ [4]

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference anifrolumab Hs Binding >10.0 pKd 1 ⤷ pKd >10.0 (Kd <1x10-10 M) [1]

Immunopharmacology Comments

IFNAR1 is a subunit of the functional receptor for type I interferons (NOT interferon γ). Type I interferons (IFN) exhibit an established anti-viral action. However, type I IFN signalling also appears to play a role in impaired resistance to a range of other pathogens (e.g. bacterial infection) [2-3]. A rare mutation in IFNAR1, identified in the Chinese population, that impairs type I IFN signalling, is associated with increased resistance to tuberculosis infection and reduced TB symptoms [5].

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Immuno Process:  T cell (activation)

Biologically Significant Variants
Type:  Insertion/deletion Species:  Human Description:  An in-frame deletion of a nucleotide codon that corresponds to a proline deletion in IFNAR1, reduces type I interferon binding affinity and increases resistance to tuberculosis infection and reduces TB pathology. Amino acid change:  Pro335del Nucleotide change:  TCCdel SNP accession:  rs72552343 References:  5