Interleukin-22 receptor α2

Target id: 1732

Nomenclature: Interleukin-22 receptor α2

Family: IL-10 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-22 receptor α2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 263 06q23.3 IL22RA2 interleukin 22 receptor subunit alpha 2
Mouse - 230 Il22ra2 interleukin 22 receptor
Rat - 229 Il22ra2 interleukin 22 receptor subunit alpha 2
Previous and Unofficial Names
CRF2-S1 | cytokine receptor family II soluble 1 | IL-22 receptor subunit alpha-2 | interleukin-22-binding protein | IL-22BP | interleukin 22 receptor, alpha 2
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
IL22RA2 (a.k.a. IL-22 binding protein) appears to act as a high affinity, soluble monomeric decoy receptor for IL-22 capable of neutralizeing the potent antimicrobial activity of IL-22 [1-2].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-22 receptor activity (GO:0042018) IDA
References: 
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of inflammatory response (GO:0050728) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of inflammatory response (GO:0050728) IEA
References: 

References

Show »

1. de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I. (2009) Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22. FEBS Lett.583 (7): 1072-7. [PMID:19285080]

2. Felix J, Savvides SN. (2017) Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures. Nat. Rev. Immunol.17 (2): 112-129. [PMID:28028310]

How to cite this page

IL-10 receptor family: Interleukin-22 receptor α2. Last modified on 06/04/2017. Accessed on 12/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1732.