Interleukin 1 receptor, type I

Target id: 1734

Nomenclature: Interleukin 1 receptor, type I

Family: Immunoglobulin-like family of IL-1 receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin 1 receptor, type I has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-1 receptor, type I
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 569 2q12 IL1R1 interleukin 1 receptor type 1
Mouse 1 576 118.81 cM Il1r1 interleukin 1 receptor, type I
Rat 1 576 9q21 Il1r1 interleukin 1 receptor type 1
Previous and Unofficial Names
CD121A | IL1RA | CD121 antigen-like family member A | IL-1R-alpha | interleukin 1 beta receptor type 1 short transmembrane form | interleukin 1 beta receptor type 1 soluble form | interleukin 1 bete receptor type 1 long transmembrane form | interleukin-1 receptor alpha | interleukin 1 receptor
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
This is one of the subunits of the functional IL-1 receptor type I heterodimer.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 5 GO processes
GO:0004908 interleukin-1 receptor activity IDA
GO:0004909 interleukin-1, Type I, activating receptor activity TAS
GO:0070498 interleukin-1-mediated signaling pathway IDA
GO:0070555 response to interleukin-1 IDA
click arrow to show/hide IEA associations
GO:2000661 positive regulation of interleukin-1-mediated signaling pathway IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0050727 regulation of inflammatory response IEA
GO:2000391 positive regulation of neutrophil extravasation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0050727 regulation of inflammatory response IEA
GO:2000391 positive regulation of neutrophil extravasation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:2000391 positive regulation of neutrophil extravasation IEA

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin 1 receptor, type I. Last modified on 22/03/2017. Accessed on 18/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1734.