Interleukin 1 receptor, type I

Target id: 1734

Nomenclature: Interleukin 1 receptor, type I

Family: Immunoglobulin-like family of IL-1 receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin 1 receptor, type I has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-1 receptor, type I
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 569 2q12 IL1R1 interleukin 1 receptor type 1
Mouse 1 576 118.81 cM Il1r1 interleukin 1 receptor, type I
Rat 1 576 9q21 Il1r1 interleukin 1 receptor type 1
Previous and Unofficial Names
CD121A | IL1RA | CD121 antigen-like family member A | IL-1R-alpha | interleukin 1 beta receptor type 1 short transmembrane form | interleukin 1 beta receptor type 1 soluble form | interleukin 1 bete receptor type 1 long transmembrane form | interleukin-1 receptor alpha
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
This is one of the subunits of the functional IL-1 receptor type I heterodimer.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-1 receptor activity (GO:0004908) IDA
interleukin-1, Type I, activating receptor activity (GO:0004909) TAS
interleukin-1-mediated signaling pathway (GO:0070498) IDA
response to interleukin-1 (GO:0070555) IDA
positive regulation of interleukin-1-mediated signaling pathway (GO:2000661) IEA
References: 
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of inflammatory response (GO:0050727) IEA
positive regulation of neutrophil extravasation (GO:2000391) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  regulation of inflammatory response (GO:0050727) IEA
positive regulation of neutrophil extravasation (GO:2000391) IEA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of neutrophil extravasation (GO:2000391) IEA
References: 

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin 1 receptor, type I. Last modified on 22/03/2017. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1734.