Interleukin-1 receptor-like 2

Target id: 1736

Nomenclature: Interleukin-1 receptor-like 2

Family: Immunoglobulin-like family of IL-1 receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-1 receptor-like 2 has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-36 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 575 02q12.1 IL1RL2 interleukin 1 receptor like 2
Mouse 1 574 Il1rl2 interleukin 1 receptor-like 2
Rat 1 561 Il1rl2 interleukin 1 receptor-like 2
Previous and Unofficial Names
IL1RRP2 | interleukin-1 receptor-related protein 2
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

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Antibodies
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Antibody Sp. Action Affinity Units Reference
MAB92 Hs Antagonist 10.6 pKd 1
pKd 10.6 (Kd 2.4x10-11 M) [1]
Immunopharmacology Comments
Interleukin-1 receptor-like 2 is one of the subunits of the functional receptor for IL-36.

An antibody that mimics IL-36RA's antagonist activity at the IL-36 receptor (MAB92) has been described [1]. MAB92 inhibits proinflammatory cytokine production in primary human keratinocytes and dermal fibroblasts in vitro. Such IL-36 antagonist antibodies are predicted to present a novel therapeutic mechanism for the treatment of epithelial cell-mediated inflammation, in particular for DITRA (deficiency of IL-36 receptor antagonist) type syndromes caused by functionally inactivating mutations in IL-36RA which leave the pro-inflammatory activity of IL-36 receptor ligands unopposed.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0004908 interleukin-1 receptor activity TAS
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GO:0004909 interleukin-1, Type I, activating receptor activity IEA
GO:0032755 positive regulation of interleukin-6 production IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes, IEA only
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GO:0006954 inflammatory response IEA
GO:0045087 innate immune response IEA
GO:0050727 regulation of inflammatory response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0045582 positive regulation of T cell differentiation IEA
GO:0050727 regulation of inflammatory response IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0045582 positive regulation of T cell differentiation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0045582 positive regulation of T cell differentiation IEA

References

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1. Ganesan R, Raymond EL, Mennerich D, Woska Jr JR, Caviness G, Grimaldi C, Ahlberg J, Perez R, Roberts S, Yang D et al.. (2017) Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies. MAbs, 9 (7): 1143-1154. [PMID:28726542]

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-1 receptor-like 2. Last modified on 25/09/2017. Accessed on 17/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1736.