Interleukin 17 receptor A | IL-17 receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

Interleukin 17 receptor A

Target id: 1738

Nomenclature: Interleukin 17 receptor A

Family: IL-17 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin 17 receptor A has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-17 receptor
Interleukin-25 receptor
Interleukin-17C receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 866 22q11.1 IL17RA interleukin 17 receptor A
Mouse 1 864 Il17ra interleukin 17 receptor A
Rat - - Il17ra interleukin 17 receptor A
Previous and Unofficial Names
CD217 | VDw217 | Interleukin-17 α receptor
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
brodalumab Hs Binding 9.2 pKd 1
pKd 9.2 (Kd 6.9x10-10 M) [1]
Immunopharmacology Comments
This protein is a common subunit shared by the heterodimeric receptors for interleukins 17 (A, B , C and F) and 25.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0030368 interleukin-17 receptor activity IBA
GO:0032747 positive regulation of interleukin-23 production IDA
GO:0097398 cellular response to interleukin-17 TAS
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GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
GO:2000664 positive regulation of interleukin-5 secretion IEA
GO:2000667 positive regulation of interleukin-13 secretion IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0071621 granulocyte chemotaxis IEA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0071621 granulocyte chemotaxis IEA

References

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1. Tocker J, Mehlin C, Lim AC. (2010) Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto. Patent number: US7767206. Assignee: Amgen Inc.. Priority date: 02/10/2006. Publication date: 03/08/2010.

How to cite this page

IL-17 receptor family: Interleukin 17 receptor A. Last modified on 07/04/2017. Accessed on 13/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1738.