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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 739 | 3p14.3 | IL17RD | interleukin 17 receptor D | |
| Mouse | 1 | 738 | 14 A3 | Il17rd | interleukin 17 receptor D | |
| Rat | - | - | Il17rd | interleukin 17 receptor D | ||
| Previous and Unofficial Names |
| SEF | IL17RLM |
| Database Links |
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| Alphafold | Q8NFM7 (Hs), Q8JZL1 (Mm) |
| CATH/Gene3D | 3.40.50.10140 |
| Ensembl Gene | ENSG00000144730 (Hs), ENSMUSG00000040717 (Mm), ENSRNOG00000021966 (Rn) |
| Entrez Gene | 54756 (Hs), 171463 (Mm), 498576 (Rn) |
| Human Protein Atlas | ENSG00000144730 (Hs) |
| KEGG Gene | hsa:54756 (Hs), mmu:171463 (Mm), rno:498576 (Rn) |
| OMIM | 606807 (Hs) |
| Pharos | Q8NFM7 (Hs) |
| UniProtKB | Q8NFM7 (Hs), Q8JZL1 (Mm) |
| Wikipedia | IL17RD (Hs) |
| Immunopharmacology Comments |
| IL17RD acts as an inhibitor of proinflammatory cytokine signaling (by limiting NF-κB translocation to the nucleus) [1], and has been reported as a feedback antagonist of receptor tyrosine kinase (RTK) signaling [3], and as a tumor suppressor gene [2,4]. |
| Immuno Process Associations | ||
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1. Fuchs Y, Brunwasser M, Haif S, Haddad J, Shneyer B, Goldshmidt-Tran O, Korsensky L, Abed M, Zisman-Rozen S, Koren L et al.. (2012) Sef is an inhibitor of proinflammatory cytokine signaling, acting by cytoplasmic sequestration of NF-κB. Dev Cell, 23 (3): 611-23. [PMID:22975329]
2. Murphy T, Darby S, Mathers ME, Gnanapragasam VJ. (2010) Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype. J Pathol, 220 (4): 452-60. [PMID:19960500]
3. Ron D, Fuchs Y, Chorev DS. (2008) Know thy Sef: a novel class of feedback antagonists of receptor tyrosine kinase signaling. Int J Biochem Cell Biol, 40 (10): 2040-52. [PMID:18450498]
4. Zisman-Rozen S, Fink D, Ben-Izhak O, Fuchs Y, Brodski A, Kraus MH, Bejar J, Ron D. (2007) Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas. Oncogene, 26 (41): 6093-8. [PMID:17420726]
IL-17 receptor family: Interleukin-17 receptor D. Last modified on 07/04/2017. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1741.
target has curated data in GtoImmuPdb
