Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	953	7p14.3	NOD1	nucleotide binding oligomerization domain containing 1
Mouse	-	953	6 B3	Nod1	nucleotide-binding oligomerization domain containing 1
Rat	-	-	4q24	Nod1	nucleotide-binding oligomerization domain containing 1

Previous and Unofficial Names

CARD4 | caspase recruitment domain family, member 4 | CLR7.1 | NLRC1 | NLR family, CARD domain containing 1 | nucleotide-binding oligomerization domain containing 1 | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1 (NLRC1)

Database Links
Alphafold	Q9Y239 (Hs), Q8BHB0 (Mm)
ChEMBL Target	CHEMBL1293222 (Hs)
Ensembl Gene	ENSG00000106100 (Hs), ENSMUSG00000038058 (Mm), ENSRNOG00000010629 (Rn)
Entrez Gene	10392 (Hs), 107607 (Mm), 500133 (Rn)
Human Protein Atlas	ENSG00000106100 (Hs)
KEGG Gene	hsa:10392 (Hs), mmu:107607 (Mm), rno:500133 (Rn)
OMIM	605980 (Hs)
Pharos	Q9Y239 (Hs)
UniProtKB	Q9Y239 (Hs), Q8BHB0 (Mm)
Wikipedia	NOD1 (Hs)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ML130 Hs Inhibition 6.3 pIC50 1 ⤷ pIC50 6.3 (IC50 5.6x10-7 M) [1]

Immunopharmacology Comments

NOD1 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing a D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety. Mutations in NOD proteins are implicated in various inflammatory diseases associated with aberrant NF-κB activity; NF-κB being a major component of the signaling pathways involved in apoptosis, inflammation, and the immune response.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Antigen presentation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling

Immuno Disease Associations

Disease Name:  Behcet syndrome Disease Synonyms:  no synonynms Comment:  Genetic variations in NOD1 are associated with Behcet's disease in a Chinese Han population, and confer disease susceptibility. Disease X-refs:  Disease Ontology: DOID:13241 OMIM: 109650 Orphanet: ORPHA117 References:  2

Physiological Functions Comments

Pro-inflammatory, involved in autophagy.