nucleotide binding oligomerization domain containing 2

Target id: 1763

Nomenclature: nucleotide binding oligomerization domain containing 2

Abbreviated Name: NOD2

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1040 16q12.1 NOD2 nucleotide binding oligomerization domain containing 2
Mouse - 1020 8 43.51 cM Nod2 nucleotide-binding oligomerization domain containing 2
Rat - - 19p11 Nod2 nucleotide-binding oligomerization domain containing 2
Previous and Unofficial Names
BLAU
CARD15
CLR16.3
IBD1
PSORAS1
caspase recruitment domain family, member 15
NLR family, CARD domain containing 2
NOD-like receptor C2
NLRC2
ACUG
NOD2B
CD
nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 (NLRC2)
nucleotide-binding oligomerization domain containing 2
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Gene
NeXtProt
OMIM
PhosphoSitePlus
TreeFam
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ML130 Hs Inhibition <4.7 pIC50 1
pIC50 <4.7 (IC50 >2x10-5 M) [1]
Physiological Functions Comments
Pro-inflammatory, involved in autophagy.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Behcet syndrome
Synonyms: Behçet disease [Orphanet: ORPHA117]
Behcet's disease [Disease Ontology: DOID:13241]
Disease Ontology: DOID:13241
OMIM: 109650
Orphanet: ORPHA117
Disease:  Blau syndrome; BLAUS
Disease Ontology: DOID:0050678
OMIM: 186580
Orphanet: ORPHA90340
Disease:  Crohn disease
Synonyms: Crohn's disease [Disease Ontology: DOID:8778]
Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
Disease:  Sarcoidosis, early-onset
Disease Ontology: DOID:11335
OMIM: 609464
Disease:  Ulcerative colitis
Synonyms: Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8577
OMIM: 266600
Orphanet: ORPHA771

References

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1. Khan PM, Correa RG, Divilianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Nov A et al.. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. ACS Med Chem Lett.2: 780-785.

How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: nucleotide binding oligomerization domain containing 2. Last modified on 29/01/2016. Accessed on 26/07/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1763.