nucleotide binding oligomerization domain containing 2

Target id: 1763

Nomenclature: nucleotide binding oligomerization domain containing 2

Abbreviated Name: NOD2

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     nucleotide binding oligomerization domain containing 2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1040 16q12.1 NOD2 nucleotide binding oligomerization domain containing 2
Mouse - 1020 8 43.51 cM Nod2 nucleotide-binding oligomerization domain containing 2
Rat - - 19p11 Nod2 nucleotide-binding oligomerization domain containing 2
Previous and Unofficial Names
BLAU | CARD15 | CLR16.3 | IBD1 | PSORAS1 | caspase recruitment domain family, member 15 | NLR family, CARD domain containing 2 | NOD-like receptor C2 | NLRC2 | CD | ACUG | NOD2B | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 (NLRC2) | nucleotide-binding oligomerization domain containing 2
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ML130 Hs Inhibition <4.7 pIC50 1
pIC50 <4.7 (IC50 >2x10-5 M) [1]
Immunopharmacology Comments
NOD2 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing muramyl dipeptide (MDP).

Mutations in NOD proteins are implicated in various inflammatory diseases associated with aberrant NF-κB activity; NF-κB being a major component of the signaling pathways involved in apoptosis, inflammation, and the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  activation of MAPK activity involved in innate immune response (GO:0035419) ISS
innate immune response (GO:0045087) IDA
regulation of inflammatory response (GO:0050727) IC
nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423) TAS
nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070431) IDA
positive regulation of cytokine production involved in inflammatory response (GO:1900017) IDA
References: 
Immuno Process:  Antigen presentation
Immuno Process ID:  3
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of dendritic cell antigen processing and presentation (GO:0002606) ISS
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of gamma-delta T cell activation (GO:0046645) ISS
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of B cell activation (GO:0050871) IDA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of dendritic cell antigen processing and presentation (GO:0002606) ISS
positive regulation of dendritic cell cytokine production (GO:0002732) IEA
positive regulation of type 2 immune response (GO:0002830) IMP
activation of MAPK activity involved in innate immune response (GO:0035419) ISS
positive regulation of gamma-delta T cell activation (GO:0046645) ISS
regulation of inflammatory response (GO:0050727) IC
positive regulation of B cell activation (GO:0050871) IDA
nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423) TAS
nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070431) IDA
positive regulation of cytokine production involved in inflammatory response (GO:1900017) IDA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  cytokine production involved in immune response (GO:0002367) IMP
cytokine secretion involved in immune response (GO:0002374) IMP
positive regulation of dendritic cell cytokine production (GO:0002732) IEA
positive regulation of interleukin-1 beta production (GO:0032731) IMP
positive regulation of interleukin-10 production (GO:0032733) ISS
positive regulation of interleukin-17 production (GO:0032740) IMP
positive regulation of interleukin-6 production (GO:0032755) IDA
positive regulation of interleukin-8 production (GO:0032757) IMP
positive regulation of tumor necrosis factor production (GO:0032760) IDA
positive regulation of interleukin-1 beta secretion (GO:0050718) IDA
positive regulation of cytokine production involved in inflammatory response (GO:1900017) IDA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of gamma-delta T cell activation (GO:0046645) ISS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  activation of MAPK activity involved in innate immune response (GO:0035419) ISS
positive regulation of gamma-delta T cell activation (GO:0046645) ISS
positive regulation of B cell activation (GO:0050871) IDA
nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423) TAS
nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070431) IDA
positive regulation of protein K63-linked ubiquitination (GO:1902523) IMP
References: 
Physiological Functions Comments
Pro-inflammatory, involved in autophagy.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Behcet syndrome
Synonyms: Behçet disease [Orphanet: ORPHA117]
Behcet's disease [Disease Ontology: DOID:13241]
Disease Ontology: DOID:13241
OMIM: 109650
Orphanet: ORPHA117
Disease:  Blau syndrome; BLAUS
Disease Ontology: DOID:0050678
OMIM: 186580
Orphanet: ORPHA90340
Disease:  Crohn's disease
Synonyms: Crohn disease [Disease Ontology: DOID:8778]
Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
Disease:  Sarcoidosis, early-onset
Disease Ontology: DOID:11335
OMIM: 609464
Disease:  Ulcerative colitis
Synonyms: Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8577
OMIM: 266600
Orphanet: ORPHA771

References

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1. Khan PM, Correa RG, Divilianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Nov A et al.. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. ACS Med Chem Lett.2: 780-785. [PMID:22003428]

Contributors

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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: nucleotide binding oligomerization domain containing 2. Last modified on 26/10/2017. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1763.