nucleotide binding oligomerization domain containing 2

Target id: 1763

Nomenclature: nucleotide binding oligomerization domain containing 2

Abbreviated Name: NOD2

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     nucleotide binding oligomerization domain containing 2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1040 16q12.1 NOD2 nucleotide binding oligomerization domain containing 2
Mouse - 1020 8 43.51 cM Nod2 nucleotide-binding oligomerization domain containing 2
Rat - - 19p11 Nod2 nucleotide-binding oligomerization domain containing 2
Previous and Unofficial Names
BLAU | CARD15 | CLR16.3 | IBD1 | PSORAS1 | caspase recruitment domain family, member 15 | NLR family, CARD domain containing 2 | NOD-like receptor C2 | NLRC2 | ACUG | NOD2B | CD | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 (NLRC2) | nucleotide-binding oligomerization domain containing 2
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ML130 Hs Inhibition <4.7 pIC50 1
pIC50 <4.7 (IC50 >2x10-5 M) [1]
Immunopharmacology Comments
NOD2 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing muramyl dipeptide (MDP).

Mutations in NOD proteins are implicated in various inflammatory diseases associated with aberrant NF-κB activity; NF-κB being a major component of the signaling pathways involved in apoptosis, inflammation, and the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 6 GO processes
GO:0035419 activation of MAPK activity involved in innate immune response ISS
GO:0045087 innate immune response IDA
GO:0050727 regulation of inflammatory response IC
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0046645 positive regulation of gamma-delta T cell activation ISS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0050871 positive regulation of B cell activation IDA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 10 GO processes
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
GO:0002830 positive regulation of type 2 immune response IMP
GO:0035419 activation of MAPK activity involved in innate immune response ISS
GO:0046645 positive regulation of gamma-delta T cell activation ISS
GO:0050727 regulation of inflammatory response IC
GO:0050871 positive regulation of B cell activation IDA
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
click arrow to show/hide IEA associations
GO:0002732 positive regulation of dendritic cell cytokine production IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 11 GO processes
GO:0002367 cytokine production involved in immune response IMP
GO:0002374 cytokine secretion involved in immune response IMP
GO:0032731 positive regulation of interleukin-1 beta production IMP
GO:0032733 positive regulation of interleukin-10 production ISS
GO:0032740 positive regulation of interleukin-17 production IMP
GO:0032755 positive regulation of interleukin-6 production IDA
GO:0032757 positive regulation of interleukin-8 production IMP
GO:0032760 positive regulation of tumor necrosis factor production IDA
GO:0050718 positive regulation of interleukin-1 beta secretion IDA
GO:1900017 positive regulation of cytokine production involved in inflammatory response IDA
click arrow to show/hide IEA associations
GO:0002732 positive regulation of dendritic cell cytokine production IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0046645 positive regulation of gamma-delta T cell activation ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
GO:0035419 activation of MAPK activity involved in innate immune response ISS
GO:0046645 positive regulation of gamma-delta T cell activation ISS
GO:0050871 positive regulation of B cell activation IDA
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
GO:1902523 positive regulation of protein K63-linked ubiquitination IMP
Physiological Functions Comments
Pro-inflammatory, involved in autophagy.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Behcet syndrome
Synonyms: Behçet disease [Orphanet: ORPHA117]
Behcet's disease [Disease Ontology: DOID:13241]
Disease Ontology: DOID:13241
OMIM: 109650
Orphanet: ORPHA117
Disease:  Blau syndrome; BLAUS
Disease Ontology: DOID:0050678
OMIM: 186580
Orphanet: ORPHA90340
Disease:  Crohn's disease
Synonyms: Crohn disease [Disease Ontology: DOID:8778]
Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
Disease:  Sarcoidosis, early-onset
Disease Ontology: DOID:11335
OMIM: 609464
Disease:  Ulcerative colitis
Synonyms: Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8577
OMIM: 266600
Orphanet: ORPHA771

References

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1. Khan PM, Correa RG, Divilianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Nov A et al.. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. ACS Med Chem Lett., 2: 780-785. [PMID:22003428]

Contributors

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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: nucleotide binding oligomerization domain containing 2. Last modified on 13/04/2018. Accessed on 24/05/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1763.