nucleotide binding oligomerization domain containing 2

Target id: 1763

Nomenclature: nucleotide binding oligomerization domain containing 2

Abbreviated Name: NOD2

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     nucleotide binding oligomerization domain containing 2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1040 16q12.1 NOD2 nucleotide binding oligomerization domain containing 2
Mouse - 1020 8 43.51 cM Nod2 nucleotide-binding oligomerization domain containing 2
Rat - - 19p11 Nod2 nucleotide-binding oligomerization domain containing 2
Previous and Unofficial Names
BLAU
CARD15
CLR16.3
IBD1
PSORAS1
caspase recruitment domain family, member 15
NLR family, CARD domain containing 2
NOD-like receptor C2
NLRC2
ACUG
NOD2B
CD
nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 (NLRC2)
nucleotide-binding oligomerization domain containing 2
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ML130 Hs Inhibition <4.7 pIC50 1
pIC50 <4.7 (IC50 >2x10-5 M) [1]
Physiological Functions Comments
Pro-inflammatory, involved in autophagy.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Behcet syndrome
Synonyms: Behçet disease [Orphanet: ORPHA117]
Behcet's disease [Disease Ontology: DOID:13241]
Disease Ontology: DOID:13241
OMIM: 109650
Orphanet: ORPHA117
Disease:  Blau syndrome; BLAUS
Disease Ontology: DOID:0050678
OMIM: 186580
Orphanet: ORPHA90340
Disease:  Crohn's disease
Synonyms: Crohn disease [Disease Ontology: DOID:8778]
Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
Disease:  Sarcoidosis, early-onset
Disease Ontology: DOID:11335
OMIM: 609464
Disease:  Ulcerative colitis
Synonyms: Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8577
OMIM: 266600
Orphanet: ORPHA771
Immunopharmacology Comments
NOD2 is an intracellular pattern recognition receptor that initiates an immune response to bacterial molecules containing muramyl dipeptide (MDP).
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  activation of MAPK activity involved in innate immune response (GO:0035419) ISS
innate immune response (GO:0045087) IDA
regulation of inflammatory response (GO:0050727) IC
nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423) TAS
nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070431) IDA
positive regulation of cytokine production involved in inflammatory response (GO:1900017) IDA
References: 
Immuno Process:  Antigen presentation
Immuno Process ID:  3
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of dendritic cell antigen processing and presentation (GO:0002606) ISS
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of gamma-delta T cell activation (GO:0046645) ISS
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of B cell activation (GO:0050871) IDA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of dendritic cell antigen processing and presentation (GO:0002606) ISS
positive regulation of dendritic cell cytokine production (GO:0002732) IEA
positive regulation of type 2 immune response (GO:0002830) IMP
activation of MAPK activity involved in innate immune response (GO:0035419) ISS
positive regulation of gamma-delta T cell activation (GO:0046645) ISS
regulation of inflammatory response (GO:0050727) IC
positive regulation of B cell activation (GO:0050871) IDA
nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423) TAS
nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070431) IDA
positive regulation of cytokine production involved in inflammatory response (GO:1900017) IDA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  cytokine production involved in immune response (GO:0002367) IMP
cytokine secretion involved in immune response (GO:0002374) IMP
positive regulation of dendritic cell cytokine production (GO:0002732) IEA
positive regulation of interleukin-1 beta production (GO:0032731) IMP
positive regulation of interleukin-10 production (GO:0032733) ISS
positive regulation of interleukin-17 production (GO:0032740) IMP
positive regulation of interleukin-6 production (GO:0032755) IDA
positive regulation of interleukin-8 production (GO:0032757) IMP
positive regulation of tumor necrosis factor production (GO:0032760) IDA
positive regulation of interleukin-1 beta secretion (GO:0050718) IDA
positive regulation of cytokine production involved in inflammatory response (GO:1900017) IDA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of gamma-delta T cell activation (GO:0046645) ISS
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  activation of MAPK activity involved in innate immune response (GO:0035419) ISS
positive regulation of gamma-delta T cell activation (GO:0046645) ISS
positive regulation of B cell activation (GO:0050871) IDA
nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423) TAS
nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070431) IDA
positive regulation of protein K63-linked ubiquitination (GO:1902523) IMP
References: 

References

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1. Khan PM, Correa RG, Divilianska DB, Peddibhotla S, Sessions EH, Magnuson G, Brown B, Suyama E, Yuan H, Mangravita-Nov A et al.. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. ACS Med Chem Lett.2: 780-785.

Contributors

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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: nucleotide binding oligomerization domain containing 2. Last modified on 22/03/2017. Accessed on 17/08/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1763.