nucleotide-binding oligomerization domain containing 2

Target id: 1763

Nomenclature: nucleotide-binding oligomerization domain containing 2

Abbreviated Name: NOD2

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1040 16q12.1 NOD2 nucleotide-binding oligomerization domain containing 2
Mouse - 1020 8 43.51 cM Nod2 nucleotide-binding oligomerization domain containing 2
Rat - - 19p11 Nod2 nucleotide-binding oligomerization domain containing 2
Previous and Unofficial Names
BLAU
CARD15
CLR16.3
IBD1
PSORAS1
caspase recruitment domain family, member 15
NLR family, CARD domain containing 2
NOD-like receptor C2
NLRC2
ACUG
NOD2B
CD
nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 (NLRC2)
Database Links
Ensembl Gene
Entrez Gene
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Gene
NeXtProt
OMIM
PhosphoSitePlus
TreeFam
UniProtKB
Wikipedia
Physiological Functions Comments
Pro-inflammatory, involved in autophagy.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Behcet syndrome
Synonyms: Behçet disease [Orphanet: ORPHA117]
Behcet's disease [Disease Ontology: DOID:13241]
Disease Ontology: DOID:13241
OMIM: 109650
Orphanet: ORPHA117
Disease:  Blau syndrome; BLAUS
Disease Ontology: DOID:0050678
OMIM: 186580
Orphanet: ORPHA90340
Disease:  Crohn disease
Synonyms: Crohn's disease [Disease Ontology: DOID:8778]
Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
Disease:  Sarcoidosis, early-onset
Disease Ontology: DOID:11335
OMIM: 609464
Disease:  Ulcerative colitis
Synonyms: Inflammatory bowel disease 1; IBD1 [OMIM: 266600]
Disease Ontology: DOID:8577
OMIM: 266600
Orphanet: ORPHA771

How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: nucleotide-binding oligomerization domain containing 2. Last modified on 14/07/2015. Accessed on 01/09/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1763.