activin A receptor type 1C | Type I receptor serine/threonine kinases | IUPHAR/BPS Guide to PHARMACOLOGY

activin A receptor type 1C

Target id: 1790

Nomenclature: activin A receptor type 1C

Abbreviated Name: ALK7

Family: Type I receptor serine/threonine kinases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for activin A receptor type 1C in GtoImmuPdb

Quaternary Structure: Complexes
Growth/differentiation factor receptors
Activin receptors
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 443 2q24.2 ACVR1C activin A receptor type 1C
Mouse 1 493 2 Acvr1c activin A receptor, type IC
Rat 1 493 3q21 Acvr1c activin A receptor type 1C
Previous and Unofficial Names
ACTR-IC | TGF-beta type 1 receptor | Alk7 | activin receptor-like kinase 7 | ACVRLK7 | activin A receptor type IC | activin A receptor
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.30
Natural/Endogenous Ligands
growth/differentiation factor-11 {Sp: Human}

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
SB-431542 Hs Inhibition - - 1-2
[1-2]
Inhibitor Comments
ACVR1C (ALK7) activity is inhibited by 99% in the presence of 2.5μM SB-431542 [2]. Alternatively 8.9% inhibition is reported using 0.1μM compound and 54% inhibition at 1μM [1].

References

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1. Li X, Wang L, Long L, Xiao J, Hu Y, Li S. (2009) Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor beta type 1 receptor (ALK5). Bioorg. Med. Chem. Lett., 19 (16): 4868-72. [PMID:19616940]

2. Schade D, Lanier M, Willems E, Okolotowicz K, Bushway P, Wahlquist C, Gilley C, Mercola M, Cashman JR. (2012) Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling. J. Med. Chem., 55 (22): 9946-57. [PMID:23130626]

How to cite this page

Type I receptor serine/threonine kinases: activin A receptor type 1C. Last modified on 30/03/2016. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1790.