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Gene and Protein Information  |
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| Adhesion G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 690 | 1p31.1 | ADGRL4 | adhesion G protein-coupled receptor L4 | |
| Mouse | 7 | 739 | 3 H3 | Adgrl4 | adhesion G protein-coupled receptor L4 | |
| Rat | 7 | 738 | 2q45 | Adgrl4 | adhesion G protein-coupled receptor L4 | 7 |
| Previous and Unofficial Names |
| ETL | EGF-TM7-latrophilin-related protein | ELTD1 | EGF, latrophilin seven transmembrane domain containing 1 |
| Database Links |
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| Specialist databases | |
| GPCRdb | agrl4_human (Hs), agrl4_mouse (Mm), agrl4_rat (Rn) |
| Other databases | |
| Alphafold | Q9HBW9 (Hs), Q923X1 (Mm), Q9ESC1 (Rn) |
| ChEMBL Target | CHEMBL4523920 (Hs) |
| Ensembl Gene | ENSG00000162618 (Hs), ENSMUSG00000039167 (Mm), ENSRNOG00000033940 (Rn) |
| Entrez Gene | 64123 (Hs), 170757 (Mm), 64124 (Rn) |
| Human Protein Atlas | ENSG00000162618 (Hs) |
| KEGG Gene | hsa:64123 (Hs), mmu:170757 (Mm), rno:64124 (Rn) |
| Pharos | Q9HBW9 (Hs) |
| RefSeq Nucleotide | NM_022159 (Hs), NM_133222 (Mm), NM_022294 (Rn) |
| RefSeq Protein | NP_071442 (Hs), NP_573485 (Mm), NP_071630 (Rn) |
| UniProtKB | Q9HBW9 (Hs), Q923X1 (Mm), Q9ESC1 (Rn) |
| Wikipedia | ADGRL4 (Hs) |
| Agonist Comments | ||
| No ligands identified: orphan receptor. |
| Tissue Distribution
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| Expression Datasets |
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| Physiological Consequences of Altering Gene Expression
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| Biologically Significant Variants
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| General Comments |
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ADGRL4 (adhesion G protein-coupled receptor L4, formerly known as ELTD1 :EGF, latrophilin and seven transmembrane domain containing 1) is an orphan receptor that belongs to Family I Adhesion-GPCRs together with latrophilins 1-3 [1]. Full coding sequence human cDNA is publicly available, IMAGE:5229055 [5] in the mammalian expression vector pCMV-SPORT6. Clone differs from genomic at rs12754818, having the more common allele. Clone represents the more common alternative transcription start site encoding a protein of 690 amino acids. ADGRL4 as a drug target: A 2017 publication validates ADGRL4 as an anti-angiogenic target for glioma [12]. In this study a mAb tageting ADGRL4 exhibited effective anti-tumour effects in preclinical glioma xenograft models, and this approach was shown to be as efficacious as anti-vascular endothelial growth factor (VEGF) and anti-MET antibody therapies. |
1. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]
2. Dieterich LC, Mellberg S, Langenkamp E, Zhang L, Zieba A, Salomäki H, Teichert M, Huang H, Edqvist PH, Kraus T et al.. (2012) Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization. J Pathol, 228 (3): 378-90. [PMID:22786655]
3. Harkensee C, Oka A, Onizuka M, Middleton PG, Inoko H, Nakaoka H, Gennery AR, Ando K, Morishima Y, Japan Marrow Donor Programme (JMDP). (2013) Microsatellite scanning of the immunogenome associates MAPK14 and ELTD1 with graft-versus-host disease in hematopoietic stem cell transplantation. Immunogenetics, 65 (6): 417-27. [PMID:23474535]
4. Lee KT, Byun MJ, Kang KS, Park EW, Lee SH, Cho S, Kim H, Kim KW, Lee T, Park JE et al.. (2011) Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study. PLoS ONE, 6 (2): e16356. [PMID:21311593]
5. Lennon G, Auffray C, Polymeropoulos M, Soares MB. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33 (1): 151-2. [PMID:8617505]
6. Martínez-Poveda B, García-Vilas JA, Cárdenas C, Melgarejo E, Quesada AR, Medina MA. (2013) The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS ONE, 8 (1): e55203. [PMID:23383109]
7. Nechiporuk T, Urness LD, Keating MT. (2001) ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. J Biol Chem, 276 (6): 4150-7. [PMID:11050079]
8. Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL. (2001) From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci USA, 98 (14): 7934-9. [PMID:11438738]
9. Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F et al.. (2013) ELTD1, a potential new biomarker for gliomas. Neurosurgery, 72 (1): 77-90; discussion 91. [PMID:23096411]
10. Wallgard E, Larsson E, He L, Hellström M, Armulik A, Nisancioglu MH, Genove G, Lindahl P, Betsholtz C. (2008) Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature. Arterioscler Thromb Vasc Biol, 28 (8): 1469-76. [PMID:18483404]
11. Xiao J, Jiang H, Zhang R, Fan G, Zhang Y, Jiang D, Li H. (2012) Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. PLoS ONE, 7 (5): e35779. [PMID:22606234]
12. Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H et al.. (2017) ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Neuro-oncology, 19 (2): 175-185. [PMID:27416955]
