ADGRE3

Target not currently curated in GtoImmuPdb

Target id: 184

Nomenclature: ADGRE3

Gene and Protein Information
Adhesion G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	652	19p13.12	ADGRE3	adhesion G protein-coupled receptor E3	8

Previous and Unofficial Names
EMR3 (EGF-like module-containing, mucin-like, hormone receptor-like 3)

Database Links
Specialist databases
GPCRdb	agre3_human (Hs)
Other databases
Alphafold	Q9BY15 (Hs)
Ensembl Gene	ENSG00000131355 (Hs)
Entrez Gene	84658 (Hs)
Human Protein Atlas	ENSG00000131355 (Hs)
KEGG Gene	hsa:84658 (Hs)
OMIM	606101 (Hs)
Pharos	Q9BY15 (Hs)
RefSeq Nucleotide	NM_032571 (Hs)
RefSeq Protein	NP_115960 (Hs)
UniProtKB	Q9BY15 (Hs)
Wikipedia	ADGRE3 (Hs)

Agonist Comments
No ligands identified: orphan receptor.

Immuno Process Associations

Immuno Process:

Inflammation

Immuno Process:

Cellular signalling

Tissue Distribution

Highest levels in the spleen, peripheral blood leukocytes and lung, followed by intermediate levels in the placenta and bone marrow, with low detected levels in the heart, kidney, liver, pancreas, skeletal muscle, lymph node, thymus, tonsil and fetal liver.
With 40 cycles of amplification two monocyte/macrophage cell lines, 2 B cell lines and one T cell line were positive while 2 firbroblast lines were negative.

Species:	Human
Technique:	RT-PCR.
References:	8

Bone marrow, spleen, lung, placenta, peripheral blood (granulocyte fraction)

Species:	Human
Technique:	Northern blot and PCR
References:	8

Primary glioblastoma tissue

Species:	Human
Technique:	Immunohistochemistry
References:	2

Upregulated in mucosa asthmatic chronic rhinosinusitis with nasal polyps

Species:	Human
Technique:	Microarray analysis
References:	7

All types of myeloid cells including neutrophilic, basophilic and eosinophilic granulocytes (high expression), monocytes and myeloid dendritic cells (weak to intermediate expression), no expression in hematopoietic stem and progenitor cells and in immature granulocytes

Species:	Human
Technique:	Flow cytometry
References:	6

Functional Assays

Expression increases in vitro invasion of glioblastoma cell line

Species:	Human
Tissue:	SF-767 cell line
Response measured:	Elevated in vitro invasion
References:	2

Physiological Functions

Potential mediator of invasive phenotypic variation in glioblastoma

Species:	Human
Tissue:	Primary glioblastoma, SF-767 cell line
References:	2

General Comments
ADGRE3 (adhesion G protein-coupled receptor E3, formerly known as EMR3: EGF-like module containing, mucin-like, hormone receptor-like 3) is an orphan receptor that belongs to Family II Adhesion-GPCRs together with ADGRE5 and ADGRE1, ADGRE2 and ADGRE4 [1,3]. The genes of Family II Adhesion-GPCRs are syntenically clustered on human chromosome 19 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [4]. No mouse or rat ADGRE3 orthologues exist. Full coding sequence human cDNA is publicly available, IMAGE:7211798 [5] in mammalian expression vector pCDNA3.1. Clone matches RefSeq and human reference genomic sequence.

General Comments

ADGRE3 (adhesion G protein-coupled receptor E3, formerly known as EMR3: EGF-like module containing, mucin-like, hormone receptor-like 3) is an orphan receptor that belongs to Family II Adhesion-GPCRs together with ADGRE5 and ADGRE1, ADGRE2 and ADGRE4 [1,3]. The genes of Family II Adhesion-GPCRs are syntenically clustered on human chromosome 19 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [4]. No mouse or rat ADGRE3 orthologues exist.

Full coding sequence human cDNA is publicly available, IMAGE:7211798 [5] in mammalian expression vector pCDNA3.1. Clone matches RefSeq and human reference genomic sequence.

References

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1. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2004) The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics, 84 (1): 23-33. [PMID:15203201]

2. Kane AJ, Sughrue ME, Rutkowski MJ, Phillips JJ, Parsa AT. (2010) EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target. Neuroreport, 21 (16): 1018-22. [PMID:20827226]

3. Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J. (2004) The EGF-TM7 family: a postgenomic view. Immunogenetics, 55 (10): 655-66. [PMID:14647991]

4. Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J. (2006) An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. FASEB J, 20 (14): 2582-4. [PMID:17068111]

5. Lennon G, Auffray C, Polymeropoulos M, Soares MB. (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics, 33 (1): 151-2. [PMID:8617505]

6. Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J. (2007) The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. J Leukoc Biol, 81 (2): 440-8. [PMID:17108056]

7. Plager DA, Kahl JC, Asmann YW, Nilson AE, Pallanch JF, Friedman O, Kita H. (2010) Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PLoS ONE, 5 (7): e11450. [PMID:20625511]

8. Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ. (2001) Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. J Biol Chem, 276 (22): 18863-70. [PMID:11279179]

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