receptor tyrosine kinase like orphan receptor 2 | Type VIII RTKs: ROR family | IUPHAR/BPS Guide to PHARMACOLOGY

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receptor tyrosine kinase like orphan receptor 2

Target not currently curated in GtoImmuPdb

Target id: 1846

Nomenclature: receptor tyrosine kinase like orphan receptor 2

Abbreviated Name: ROR2

Family: Type VIII RTKs: ROR family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 943 9q22 ROR2 receptor tyrosine kinase like orphan receptor 2
Mouse 1 944 13 B3 Ror2 receptor tyrosine kinase-like orphan receptor 2
Rat - 943 17p14 Ror2 receptor tyrosine kinase-like orphan receptor 2
Previous and Unofficial Names
BDB | BDB1 | NTRKR2 | Neurotrophic tyrosine kinase, receptor-related 2
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.10.1
Antibody Comments
BioAtla have developed a conditionally active anti-ROR2 antibody drug conjugate (referred to as BA3021 or CAB-ROR2-ADC) as a novel antineoplastic. It is claimed that the binding of BA3021 to ROR2 is conditional upon factors that are present in the tumour microenvironment (due to the Warburg effect), and that BA3021-ROR2 binding does not occur in normal tissues. The full mechanism of action of BA3021 has not yet been fully disclosed (Feb 2019). BA3021 is being evaluated as a monotherapy in Phase 1/2 clinical trial NCT03504488, in patients with various solid tumour types, including non-small cell lung cancer, triple negative breast cancer and soft tissue sarcoma. BA3021 was granted FDA orphan designation for soft tissue sarcoma in December 2018 [1]. IMGT list this antibody construct with ID 883.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Brachydactyly, type B1; BDB1
Synonyms: Brachydactyly [Disease Ontology: DOID:0050581]
Brachydactyly type B [Orphanet: ORPHA93383]
Disease Ontology: DOID:0050581
OMIM: 113000
Orphanet: ORPHA93383
Disease:  Robinow syndrome, autosomal recessive
OMIM: 268310
Orphanet: ORPHA1507

References

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1. FDA. Orphan drug designation for conditionally active biologics-anti-ROR2-antibody drug conjugate. Accessed on 14/02/2019. Modified on 14/02/2019. www.accessdata.fda.gov, https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=663018

How to cite this page

Type VIII RTKs: ROR family : receptor tyrosine kinase like orphan receptor 2. Last modified on 20/03/2019. Accessed on 19/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1846.