RTP Type B

Target id: 1851

Nomenclature: RTP Type B

Family: Receptor tyrosine phosphatase (RTP) family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for RTP Type B in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - PTPRB protein tyrosine phosphatase, receptor type B
Mouse - - Ptprb protein tyrosine phosphatase
Rat - - Ptprb protein tyrosine phosphatase
Previous and Unofficial Names
vascular endothelial protein tyrosine phosphatase | VEPTP | protein tyrosine phosphatase, receptor type, B | protein tyrosine phosphatase
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 13e [PMID: 16759857] Hs Inhibition 7.2 pIC50 1
pIC50 7.2 (IC50 7x10-8 M) [1]
General Comments
RTP Type B (HPTPβ) is mainly expressed in endothelial cells and negatively regulates Tie2 (TEK) activity (by de-phosphorylation) [2]. Since Tie2 is a receptor tyrosine kinase for the angiopoietin growth factors [3], RTP Type B may also be important in vascular biology [4].

References

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1. Amarasinghe KK, Evdokimov AG, Evidokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE et al.. (2006) Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg. Med. Chem. Lett.16 (16): 4252-6. [PMID:16759857]

2. Fachinger G, Deutsch U, Risau W. (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene18 (43): 5948-53. [PMID:10557082]

3. Gale NW, Yancopoulos GD. (1999) Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev.13 (9): 1055-66. [PMID:10323857]

4. Wright MB, Seifert RA, Bowen-Pope DF. (2000) Protein-tyrosine phosphatases in the vessel wall: differential expression after acute arterial injury. Arterioscler. Thromb. Vasc. Biol.20 (5): 1189-98. [PMID:10807732]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type B. Last modified on 17/09/2015. Accessed on 16/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1851.