RTP Type C

Target id: 1852

Nomenclature: RTP Type C

Family: Receptor tyrosine phosphatase (RTP) family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     RTP Type C has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - PTPRC protein tyrosine phosphatase, receptor type C
Mouse - - Ptprc protein tyrosine phosphatase, receptor type, C
Rat - - Ptprc protein tyrosine phosphatase, receptor type, C
Previous and Unofficial Names
RT7 | protein tyrosine phosphatase, receptor type, C | T200 glycoprotein | CD45 | gp180 | LCA | Ly-5 | Lyt-4 | T200 leukocyte common antigen | protein tyrosine phosphatase
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Natural/Endogenous Ligands
galectin-1 {Sp: Human}
Comments: Putative endogenous ligand.
Immunopharmacology Comments
CD45 is a high molecular weight cell surface glycoprotein expressed by cells of hematopoietic origin. Alternate transcripts lead to expression of isoforms that differ in their extracellular (ligand binding) domain (potentially facilitating differential and/or cell type specific biological functions [1]) but all contain the same intracellular domain that has tyrosine phosphatase activity. In relation to immune pathology, a single report from 1992 notes the presence of autoantibodies to CD45 in serum from patients with active systemic lupus erythematosus [2].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS
GO:0030217 T cell differentiation ISS
GO:0042102 positive regulation of T cell proliferation ISS
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 3 GO processes
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS
GO:0030890 positive regulation of B cell proliferation IMP
GO:0042100 B cell proliferation ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 6 GO processes
GO:0001915 negative regulation of T cell mediated cytotoxicity ISS
GO:0030890 positive regulation of B cell proliferation IMP
GO:0042102 positive regulation of T cell proliferation ISS
GO:0050852 T cell receptor signaling pathway IDA
GO:0050853 B cell receptor signaling pathway ISS
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes
GO:0002244 hematopoietic progenitor cell differentiation IMP
GO:0030217 T cell differentiation ISS
GO:0048539 bone marrow development IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0001960 negative regulation of cytokine-mediated signaling pathway ISS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0042102 positive regulation of T cell proliferation ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 8 GO processes
GO:0030217 T cell differentiation ISS
GO:0030890 positive regulation of B cell proliferation IMP
GO:0042100 B cell proliferation ISS
GO:0042102 positive regulation of T cell proliferation ISS
GO:0043312 neutrophil degranulation TAS
GO:0050852 T cell receptor signaling pathway IDA
GO:0050853 B cell receptor signaling pathway ISS
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway ISS

References

Show »

1. Dalchau R, Fabre JW. (1981) Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule. J. Exp. Med., 153 (4): 753-65. [PMID:6166706]

2. Winfield JB, Mimura T, Fernsten PD. (1992) Autoantibodies to CD45 in systemic lupus erythematosus. Int. J. Clin. Lab. Res., 21 (4): 292-5. [PMID:1534265]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type C. Last modified on 19/04/2017. Accessed on 19/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1852.