RTP Type F

Target id: 1855

Nomenclature: RTP Type F

Family: Receptor tyrosine phosphatase (RTP) family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for RTP Type F in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - PTPRF protein tyrosine phosphatase, receptor type F
Mouse - - Ptprf protein tyrosine phosphatase, receptor type, F
Rat - - Ptprf protein tyrosine phosphatase, receptor type, F
Previous and Unofficial Names
LARFN5C | leukocyte antigen-related (LAR) PTP receptor | protein tyrosine phosphatase, receptor type, F | protein tyrosine phosphatase
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Putative endogenous ligands
netrin-G3 ligand (LRRC4B, Q9NT99)  [1]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
illudalic acid Hs Inhibition 5.9 pIC50 2
pIC50 5.9 (IC50 1.3x10-6 M) [2]
Description: Measured utilising purified recombinant LAR catalytic domain.

References

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1. Kwon SK, Woo J, Kim SY, Kim H, Kim E. (2010) Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. J. Biol. Chem.285 (18): 13966-78. [PMID:20139422]

2. Ling Q, Huang Y, Zhou Y, Cai Z, Xiong B, Zhang Y, Ma L, Wang X, Li X, Li J et al.. (2008) Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg. Med. Chem.16 (15): 7399-409. [PMID:18579388]

How to cite this page

Receptor tyrosine phosphatase (RTP) family: RTP Type F. Last modified on 15/09/2015. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1855.