CD40

Target id: 1874

Nomenclature: CD40

Systematic Nomenclature: TNFRSF5

Family: Immune checkpoint catalytic receptors, Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     CD40 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 277 20q13.12 CD40 CD40 molecule
Mouse 1 289 Cd40 CD40 antigen
Rat - - Cd40 CD40 molecule
Previous and Unofficial Names
CD40 molecule, TNF receptor superfamily member 5 | TNFRSF5
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Adaptor proteins (Human)
TRAF1, TRAF2, TRAF3, TRAF5, TRAF6
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CD40 ligand {Sp: Human} Hs - - -
Immunopharmacology Comments
A costimulatory protein found on antigen presenting cells, required for their activation. Endogenous ligand is CD154 (CD40L) on TH cells.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  inflammatory response (GO:0006954) IBA
response to interferon-gamma (GO:0034341) IEA
positive regulation of isotype switching to IgG isotypes (GO:0048304) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of B cell proliferation (GO:0030890) IEA
B cell proliferation (GO:0042100) NAS
positive regulation of isotype switching to IgG isotypes (GO:0048304) IEA
regulation of immunoglobulin secretion (GO:0051023) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  immune response-regulating cell surface receptor signaling pathway (GO:0002768) IEA
positive regulation of B cell proliferation (GO:0030890) IEA
positive regulation of isotype switching to IgG isotypes (GO:0048304) IEA
regulation of immune response (GO:0050776) TAS
regulation of immunoglobulin secretion (GO:0051023) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  tumor necrosis factor-activated receptor activity (GO:0005031) IBA
positive regulation of interleukin-12 production (GO:0032735) IEA
tumor necrosis factor-mediated signaling pathway (GO:0033209) TAS
response to interferon-gamma (GO:0034341) IEA
cellular response to erythropoietin (GO:0036018) IEA
cellular response to interleukin-1 (GO:0071347) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  immune response-regulating cell surface receptor signaling pathway (GO:0002768) IEA
positive regulation of B cell proliferation (GO:0030890) IEA
B cell proliferation (GO:0042100) NAS
positive regulation of isotype switching to IgG isotypes (GO:0048304) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of isotype switching to IgG isotypes (GO:0048304) IEA
References: 
Immuno Process:  Immune system development
Immuno Process ID:  8
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of isotype switching to IgG isotypes (GO:0048304) IEA
References: 

How to cite this page

Immune checkpoint catalytic receptors: CD40. Last modified on 03/07/2017. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1874.