herpes virus entry mediator

Target id: 1887

Nomenclature: herpes virus entry mediator

Abbreviated Name: HVEM

Systematic Nomenclature: TNFRSF14

Family: Immune checkpoint catalytic receptors, Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     herpes virus entry mediator has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 283 01p36.32 TNFRSF14 TNF receptor superfamily member 14
Mouse - - Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Rat - - Tnfrsf14 TNF receptor superfamily member 14
Previous and Unofficial Names
ATAR | Herpesvirus entry mediator A | HVEA | HVEM | TR2 | tumor necrosis factor receptor superfamily, member 14 | CD270 | LIGHTR | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Adaptor proteins (Human)
TRAF2, TRAF3, TRAF5
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
B and T lymphocyte attenuator {Sp: Human} Hs - - -
lymphotoxin-α {Sp: Human} Hs - - -
LIGHT {Sp: Human} Hs - - -
Immunopharmacology Comments
HSV viral envelope glycoprotein D (gD) binds to this protein and thereby gains entry to the cell. HVEM binds to several TRAFadaptor proteins to mediate intracellular signalling and activation of the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  inflammatory response (GO:0006954) IBA
positive regulation of T cell migration (GO:2000406) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell costimulation (GO:0031295) TAS
negative regulation of alpha-beta T cell proliferation (GO:0046642) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of cytokine secretion involved in immune response (GO:0002741) IEA
T cell costimulation (GO:0031295) TAS
negative regulation of alpha-beta T cell proliferation (GO:0046642) IEA
positive regulation of T cell migration (GO:2000406) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of cytokine secretion involved in immune response (GO:0002741) IEA
tumor necrosis factor-activated receptor activity (GO:0005031) TAS
tumor necrosis factor-mediated signaling pathway (GO:0033209) TAS
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell costimulation (GO:0031295) TAS
negative regulation of alpha-beta T cell proliferation (GO:0046642) IEA
positive regulation of T cell migration (GO:2000406) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  T cell costimulation (GO:0031295) TAS
negative regulation of alpha-beta T cell proliferation (GO:0046642) IEA
References: 
Immuno Process:  Barrier integrity
Immuno Process ID:  1
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  virus receptor activity (GO:0001618) IEA
References: 

How to cite this page

Immune checkpoint catalytic receptors: herpes virus entry mediator. Last modified on 03/07/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1887.