herpes virus entry mediator

Target id: 1887

Nomenclature: herpes virus entry mediator

Abbreviated Name: HVEM

Systematic Nomenclature: TNFRSF14

Family: Immune checkpoint catalytic receptors, Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     herpes virus entry mediator has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 283 01p36.32 TNFRSF14 TNF receptor superfamily member 14
Mouse - - Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Rat - - Tnfrsf14 TNF receptor superfamily member 14
Previous and Unofficial Names
ATAR | Herpesvirus entry mediator A | HVEA | HVEM | TR2 | tumor necrosis factor receptor superfamily, member 14 | CD270 | LIGHTR | tumor necrosis factor receptor superfamily | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Adaptor proteins (Human)
TRAF2, TRAF3, TRAF5
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
B and T lymphocyte attenuator {Sp: Human} Hs - - -
lymphotoxin-α {Sp: Human} Hs - - -
LIGHT {Sp: Human} Hs - - -
Immunopharmacology Comments
HSV viral envelope glycoprotein D (gD) binds to this protein and thereby gains entry to the cell. HVEM binds to several TRAFadaptor proteins to mediate intracellular signalling and activation of the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0006954 inflammatory response IBA
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GO:2000406 positive regulation of T cell migration IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0031295 T cell costimulation TAS
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GO:0046642 negative regulation of alpha-beta T cell proliferation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0031295 T cell costimulation TAS
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GO:0002741 positive regulation of cytokine secretion involved in immune response IEA
GO:0046642 negative regulation of alpha-beta T cell proliferation IEA
GO:2000406 positive regulation of T cell migration IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0005031 tumor necrosis factor-activated receptor activity TAS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
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GO:0002741 positive regulation of cytokine secretion involved in immune response IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 3 GO processes
GO:0031295 T cell costimulation TAS
click arrow to show/hide IEA associations
GO:0046642 negative regulation of alpha-beta T cell proliferation IEA
GO:2000406 positive regulation of T cell migration IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes
GO:0031295 T cell costimulation TAS
click arrow to show/hide IEA associations
GO:0046642 negative regulation of alpha-beta T cell proliferation IEA
Immuno Process:  Barrier integrity
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0001618 virus receptor activity IEA

How to cite this page

Immune checkpoint catalytic receptors: herpes virus entry mediator. Last modified on 09/02/2018. Accessed on 24/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1887.