glucocorticoid-induced TNF receptor | Tumour necrosis factor (TNF) receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

glucocorticoid-induced TNF receptor

Target id: 1890

Nomenclature: glucocorticoid-induced TNF receptor

Abbreviated Name: GITR

Systematic Nomenclature: TNFRSF18

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     glucocorticoid-induced TNF receptor has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 241 01p36.33 TNFRSF18 TNF receptor superfamily member 18
Mouse 1 228 Tnfrsf18 tumor necrosis factor receptor superfamily, member 18
Rat - - Tnfrsf18 TNF receptor superfamily member 18
Previous and Unofficial Names
activation-inducible TNFR family receptor | AITR | Glucocorticoid-induced TNFR-related protein | tumor necrosis factor receptor superfamily, member 18 | CD357 | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Adaptor proteins (Human)
TRAF1, TRAF2, TRAF3, SIVA
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
TL6 {Sp: Human} Hs - - -
Immunopharmacology Comments
GITR appears to act as a co-stimulatory immune checkpoint molecule. T cell activation induces GITR expression. GITR inhibits the suppressive activity of Treg cells and promotes survival of Teff cells.
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0045589 regulation of regulatory T cell differentiation TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045589 regulation of regulatory T cell differentiation TAS
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0002687 positive regulation of leukocyte migration IMP
GO:0006954 inflammatory response IBA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045589 regulation of regulatory T cell differentiation TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0002687 positive regulation of leukocyte migration IMP
GO:0045589 regulation of regulatory T cell differentiation TAS
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0005031 tumor necrosis factor-activated receptor activity IBA
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
GO:0002687 positive regulation of leukocyte migration IMP
GO:0045589 regulation of regulatory T cell differentiation TAS

Contributors

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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: glucocorticoid-induced TNF receptor. Last modified on 22/03/2017. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1890.