ADGRF2

Target id: 191

Nomenclature: ADGRF2

Family: Adhesion Class GPCRs

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ADGRF2 in GtoImmuPdb

Gene and Protein Information
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 642 6p12.3 ADGRF2 adhesion G protein-coupled receptor F2
Mouse 7 644 17 B3 Adgrf2 adhesion G protein-coupled receptor F2
Rat 7 650 9q12 Adgrf2 adhesion G protein-coupled receptor F2
Previous and Unofficial Names
GPR111 (G protein-coupled receptor 111)
Database Links
Specialist databases
GPCRDB agrf2_human (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Heart, skin, spleen, testis, brain, tongue, esophagus, forestomach
Species:  Mouse
Technique:  RT-PCR and LacZ insertion
References:  3
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Functions
Skin barrier assay
Species:  Mouse
Tissue:  Skin
References:  3
Physiological Consequences of Altering Gene Expression Comments
Adgrf2 knockout mice do not show defects in development or fertility [3].
General Comments
ADGRF2 (formerly GPR111) is an orphan receptor that belongs to Family VI Adhesion-GPCRs together with ADGRF1 and ADGRF3-5 [1]. The genes of Family VI Adhesion-GPCRs except ADGRF3 are syntenically clustered on human chromosome 6 and mouse chromosome 17 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [3].

Original gene prediction [2] failed to predict several exons at both the 5' and 3' ends and included one exon of ADGRF2 in the prediction of ADGRF4 which is the adjacent gene.

A rat cDNA similar to the mouse cDNA AK142836 can be predicted with an open reading frame of 650 amino acids.

References

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1. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem. Biophys. Res. Commun., 301 (3): 725-34. [PMID:12565841]

2. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett, 531: 407-414. [PMID:12435584]

3. Prömel S, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Grosse J, Schöneberg T, Russ AP et al.. (2012) Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev. Dyn., 241 (10): 1591-602. [PMID:22837050]

Contributors

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How to cite this page

Tobias Langenhan, Simone Prömel, Tom I. Bonner.
Adhesion Class GPCRs: ADGRF2. Last modified on 03/03/2017. Accessed on 22/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=191.