Contents:
| Quaternary Structure: Complexes |
| GABAB receptor |
Gene and Protein Information  |
||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | References |
| Mouse | - | 292 | X F3 | Kctd12b | potassium channel tetramerisation domain containing 12b | 1 |
| Database Links |
|
| Alphafold | Q8C7J6 (Mm) |
| Ensembl Gene | ENSMUSG00000041633 (Mm) |
| Entrez Gene | 207474 (Mm) |
| KEGG Gene | mmu:207474 (Mm) |
| RefSeq Nucleotide | NM_175429 (Mm) |
| RefSeq Protein | NP_780638 (Mm) |
| UniProtKB | Q8C7J6 (Mm) |
| Protein Comments |
| KCTD proteins act as auxiliary subunits of GABAB receptors that determine the pharmacology and kinetics of the receptor response. GABAB receptors assemble from principle and auxiliary subunits. The principle subunits GABAB1 and GABAB2 form functional heteromeric GABAB(1,2) receptors that associate with homotetramers of auxiliary KCTD8, 12, 12b or 16 (named after their K+ channel tetramerization domain) subunits [1-2]. |
References
1. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K et al.. (2010) Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Nature, 465 (7295): 231-5. [PMID:20400944]
2. Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M, Bettler B. (2012) Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitization. J Biol Chem, 287 (47): 39869-77. [PMID:23035119]
How to cite this page
kctd12b. Last modified on 02/03/2017. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1919.
