cyclin dependent kinase 13 | CRK7 subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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cyclin dependent kinase 13

Target id: 1966

Nomenclature: cyclin dependent kinase 13

Abbreviated Name: CDK13

Family: CRK7 subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for cyclin dependent kinase 13 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1512 7p14.1 CDK13 cyclin dependent kinase 13
Mouse - 1511 13 A3.1 Cdk13 cyclin-dependent kinase 13
Rat - 1511 17 q12.1 Cdk13 cyclin-dependent kinase 13
Previous and Unofficial Names
CDC2L | CDC2L5 | CDC2-related protein kinase 5 | cell division cycle 2-like 5 | cell division protein kinase 13
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.22
EC Number: 2.7.11.23

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CDK12 inhibitor 2 Hs Inhibition 8.0 pIC50 2
pIC50 8.0 (IC50 1x10-8 M) [2]
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target used in screen: CDC2L5
Ligand Sp. Type Action Affinity Units
AST-487 Hs Inhibitor Inhibition 9.0 pKd
AT-7519 Hs Inhibitor Inhibition 8.5 pKd
BMS-387032 Hs Inhibitor Inhibition 7.6 pKd
linifanib Hs Inhibitor Inhibition 7.4 pKd
staurosporine Hs Inhibitor Inhibition 7.2 pKd
R547 Hs Inhibitor Inhibition 7.0 pKd
foretinib Hs Inhibitor Inhibition 6.7 pKd
alvocidib Hs Inhibitor Inhibition 6.4 pKd
BMS-345541 Hs Inhibitor Inhibition 6.1 pKd
lestaurtinib Hs Inhibitor Inhibition 6.0 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Ito M, Tanaka T, Toita A, Uchiyama N, Kokubo H, Morishita N, Klein MG, Zou H, Murakami M, Kondo M et al.. (2018) Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors. J. Med. Chem., 61 (17): 7710-7728. [PMID:30067358]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

CRK7 subfamily: cyclin dependent kinase 13. Last modified on 28/08/2018. Accessed on 21/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1966.