cyclin-dependent kinase 14

Target id: 1967

Nomenclature: cyclin-dependent kinase 14

Abbreviated Name: CDK14

Family: TAIRE subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 451 7q21-q22 CDK14 cyclin-dependent kinase 14
Mouse - 469 5 A1 Cdk14 cyclin-dependent kinase 14
Rat - 279 4q12-q13 Cdk14 cyclin-dependent kinase 14
Previous and Unofficial Names
cell division protein kinase 14
PFTAIRE protein kinase 1
PFTAIRE1
PFTK1
Database Links
BRENDA
Ensembl Gene
Entrez Gene
ExplorEnz
GeneCards
GenitoUrinary Development Molecular Anatomy Project
HomoloGene
Human Protein Reference Database
InterPro
KEGG BRITE Hierarchy
KEGG Gene
OMIM
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: PFTK1
Ligand Sp. Type Action Affinity Units
R547 Hs Inhibitor Inhibition 7.96 pKd
AT-7519 Hs Inhibitor Inhibition 7.8 pKd
AST-487 Hs Inhibitor Inhibition 7.77 pKd
foretinib Hs Inhibitor Inhibition 7.51 pKd
alvocidib Hs Inhibitor Inhibition 6.96 pKd
staurosporine Hs Inhibitor Inhibition 6.8 pKd
sunitinib Hs Inhibitor Inhibition 6.57 pKd
BMS-387032 Hs Inhibitor Inhibition 6.16 pKd
lestaurtinib Hs Inhibitor Inhibition 6.14 pKd
A-674563 Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

Show »

1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol.29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol.17 (11): 1241-9. [PMID:21095574]

How to cite this page

TAIRE subfamily: cyclin-dependent kinase 14. Last modified on 18/08/2014. Accessed on 22/11/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1967.