Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	435	2q33.1	CDK15	cyclin dependent kinase 15
Mouse	-	433	1 C1.3	Cdk15	cyclin dependent kinase 15
Rat	-	437	9q31	Cdk15	cyclin-dependent kinase 15

Previous and Unofficial Names

ALS2CR7 | PFTAIRE protein kinase 2 | PFTAIRE2 | Cell division protein kinase 15 | frizzled family receptor 7 | cyclin-dependent kinase 15

Database Links
Alphafold	Q96Q40 (Hs), Q3V3A1 (Mm)
BRENDA	2.7.11.22
ChEMBL Target	CHEMBL5856 (Hs)
Ensembl Gene	ENSG00000138395 (Hs), ENSMUSG00000026023 (Mm), ENSRNOG00000022899 (Rn)
Entrez Gene	65061 (Hs), 271697 (Mm), 301440 (Rn)
Human Protein Atlas	ENSG00000138395 (Hs)
KEGG Enzyme	2.7.11.22
KEGG Gene	hsa:65061 (Hs), mmu:271697 (Mm), rno:301440 (Rn)
Pharos	Q96Q40 (Hs)
RefSeq Nucleotide	NM_001261435 (Hs), NM_001033373 (Mm), XM_237191 (Rn)
RefSeq Protein	NP_631897 (Hs), NP_001028545 (Mm), XP_237191 (Rn)
UniProtKB	Q96Q40 (Hs), Q3V3A1 (Mm)
Wikipedia	CDK15 (Hs)

Enzyme Reaction
EC Number: 2.7.11.22

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: PFTAIRE2
Ligand Sp. Type Action Value Parameter R547 Hs Inhibitor Inhibition 8.1 pKd foretinib Hs Inhibitor Inhibition 7.5 pKd AT-7519 Hs Inhibitor Inhibition 7.2 pKd AST-487 Hs Inhibitor Inhibition 7.1 pKd staurosporine Hs Inhibitor Inhibition 6.6 pKd alvocidib Hs Inhibitor Inhibition 6.5 pKd PHA-665752 Hs Inhibitor Inhibition 6.3 pKd BMS-387032 Hs Inhibitor Inhibition 6.1 pKd lestaurtinib Hs Inhibitor Inhibition 5.9 pKd bosutinib Hs Inhibitor Inhibition 5.8 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »