<i>GPR143</i> | Other 7TM proteins | IUPHAR/BPS Guide to PHARMACOLOGY

GPR143

Target id: 203

Nomenclature: GPR143

Family: Other 7TM proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR143 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 404 Xp22.3 GPR143 G protein-coupled receptor 143
Mouse 7 405 X F2-F3 Gpr143 G protein-coupled receptor 143
Rat 7 405 Xq21 Gpr143 G protein-coupled receptor 143
Previous and Unofficial Names
MOA1 | ocular albinism 1 (Nettleship-Falls) | NYS6 | Ocular albinism type 1 protein
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005101 abnormal ciliary body pigmentation PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005199 abnormal iris pigment epithelium PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005075 abnormal melanosome morphology PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0002864 abnormal ocular fundus morphology PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0001332 abnormal optic nerve innervation PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005200 abnormal pigment epithelium of the eye PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005103 abnormal retinal pigmentation PMID: 11092754 
Gpr143tm1Inc Gpr143tm1Inc/Y
either: (involves: 129/Sv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MGI:107193  MP:0005201 abnormal retinal pigment epithelium morphology PMID: 11092754 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Nystagmus 6, congenital, X-linked; NYS6
Synonyms: Congenital nystagmus [Disease Ontology: DOID:9649]
Idiopathic infantile nystagmus [Orphanet: ORPHA651]
Disease Ontology: DOID:9649
OMIM: 300814
Orphanet: ORPHA651
Disease:  Ocular albinism, type I; OA1
Synonyms: Ocular albinism [Disease Ontology: DOID:0050633]
X-linked recessive ocular albinism [Orphanet: ORPHA54]
Disease Ontology: DOID:0050633
OMIM: 300500
Orphanet: ORPHA54
General Comments
GPR143 shows no homology to known G protein-coupled receptors.

Contributors

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How to cite this page

Tom I. Bonner.
Other 7TM proteins: GPR143. Last modified on 27/01/2015. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=203.