mitogen-activated protein kinase kinase kinase 12

Target id: 2072

Nomenclature: mitogen-activated protein kinase kinase kinase 12

Abbreviated Name: DLK

Family: LZK subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for mitogen-activated protein kinase kinase kinase 12 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 859 12q13 MAP3K12 mitogen-activated protein kinase kinase kinase 12
Mouse - 888 15 F3 Map3k12 mitogen-activated protein kinase kinase kinase 12
Rat - 888 7 q36 Map3k12 mitogen activated protein kinase kinase kinase 12
Previous and Unofficial Names
dual leucine zipper kinase DLK | MAPK-upstream kinase | MEKK12 | MUK | ZPKP1
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: DLK
Ligand Sp. Type Action Affinity Units
foretinib Hs Inhibitor Inhibition 7.7 pKd
NVP-TAE684 Hs Inhibitor Inhibition 7.4 pKd
KW-2449 Hs Inhibitor Inhibition 7.2 pKd
sunitinib Hs Inhibitor Inhibition 7.0 pKd
crizotinib Hs Inhibitor Inhibition 6.8 pKd
tozasertib Hs Inhibitor Inhibition 6.7 pKd
JNJ-28312141 Hs Inhibitor Inhibition 6.5 pKd
neratinib Hs Inhibitor Inhibition 6.4 pKd
SU-14813 Hs Inhibitor Inhibition 6.3 pKd
bosutinib Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »


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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

LZK subfamily: mitogen-activated protein kinase kinase kinase 12. Last modified on 22/03/2013. Accessed on 25/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY,