<i>GPR179</i> | Class C Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

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GPR179

Target id: 211

Nomenclature: GPR179

Family: Class C Orphans

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR179 in GtoImmuPdb

Gene and Protein Information
class C G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 2367 17q21.1 GPR179 G protein-coupled receptor 179
Mouse 7 2293 11 D Gpr179 G protein-coupled receptor 179
Rat 7 2309 10q31 Gpr179 G protein-coupled receptor 179
Previous and Unofficial Names
GPR158-like 1
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution
Full length cDNA (AY584611) from pituitary, unigene ESTs from heart, brain and eye.
Species:  Human
Technique: 
References: 
ESTs from pituitary, hypothalamus and brain.
Species:  Mouse
Technique: 
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Night blindness, congenital stationary, type 1E; CSNB1E
Synonyms: Congenital stationary night blindness [Orphanet: ORPHA215] [Disease Ontology: DOID:0050534]
Disease Ontology: DOID:0050534
OMIM: 614565
Orphanet: ORPHA215
References:  1
General Comments
Protein sequence similar to GPR158 but with much larger carboxyl terminal intracellular domain. 44% amino acid identity between human GPR158 and GPR179 excluding the carboxyl terminal domain.

References

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1. Peachey NS, Ray TA, Florijn R, Rowe LB, Sjoerdsma T, Contreras-Alcantara S, Baba K, Tosini G, Pozdeyev N, Iuvone PM et al.. (2012) GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness. Am. J. Hum. Genet., 90 (2): 331-9. [PMID:22325362]

Contributors

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How to cite this page

Hans Bräuner-Osborne.
Class C Orphans: GPR179. Last modified on 29/01/2015. Accessed on 17/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=211.