phosphatidylinositol 4-kinase beta

Target id: 2149

Nomenclature: phosphatidylinositol 4-kinase beta

Abbreviated Name: PI4KIIIβ/PIK4CB

Family: 1-phosphatidylinositol 4-kinase family, Phosphatidylinositol kinases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for phosphatidylinositol 4-kinase beta in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 828 1q21 PI4KB phosphatidylinositol 4-kinase beta
Mouse - 801 3 F2.1 Pi4kb phosphatidylinositol 4-kinase beta
Rat - 816 2 q34 Pi4kb phosphatidylinositol 4-kinase beta
Previous and Unofficial Names
PI4Kbeta | ptdIns 4-kinase beta | phosphatidylinositol 4-kinase, catalytic, beta | phosphatidylinositol 4-kinase, catalytic, beta polypeptide
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.1.67
Endogenous activation
PKD-mediated phosphorylation  [4]

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
torin 2 Hs Inhibition 7.7 pIC50 7
pIC50 7.7 (IC50 1.83x10-8 M) [7]
PIK-93 Hs Inhibition 7.7 pIC50 1,6
pIC50 7.7 (IC50 1.9x10-8 M) [1,6]
wortmannin Hs Inhibition 6.7 – 6.8 pIC50 3,8
pIC50 6.7 – 6.8 [3,8]
Tissue Distribution
Intracellular membranes, with prominent co-localization with early endosomes and recycling endosomes but not with the Golgi.
Species:  Human
Technique:  Immunocytochemistry and confocal microscopy using epitope-tagged and green fluorescent protein-tagged enzyme expressed in COS-7 cells.
References:  2
Physiological Functions
PI4KIIIβ is responsible for controlling the exit of LIMP-2 from the Golgi. LIMP-2 is a receptor for transport of β-glucocerebrosidase into lysosomes. β-glucocerebrosidase (GBA) is the Gaucher disease enzyme.
Species:  Human
Tissue:  COS-7 cells transfected with photoactivatable LIMP-2
References:  5

References

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1. Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T. (2008) Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol. Biol. Cell19 (2): 711-21. [PMID:18077555]

2. Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T. (2002) Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. J. Biol. Chem.277 (22): 20041-50. [PMID:11923287]

3. Gehrmann T, Gülkan H, Suer S, Herberg FW, Balla A, Vereb G, Mayr GW, Heilmeyer Jr LM. (1999) Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230. Biochim. Biophys. Acta1437 (3): 341-56. [PMID:10101268]

4. Hausser A, Storz P, Märtens S, Link G, Toker A, Pfizenmaier K. (2005) Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nat. Cell Biol.7 (9): 880-6. [PMID:16100512]

5. Jović M, Kean MJ, Szentpetery Z, Polevoy G, Gingras AC, Brill JA, Balla T. (2012) Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase. Mol. Biol. Cell23 (8): 1533-45. [PMID:22337770]

6. Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B et al.. (2006) A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell125 (4): 733-47. [PMID:16647110]

7. Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS. (2011) Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J. Med. Chem.54 (5): 1473-80. [PMID:21322566]

8. Meyers R, Cantley LC. (1997) Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J. Biol. Chem.272 (7): 4384-90. [PMID:9020160]

How to cite this page

Phosphatidylinositol kinases: phosphatidylinositol 4-kinase beta. Last modified on 06/06/2016. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2149.