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D2 receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 215

Nomenclature: D2 receptor

Family: Dopamine receptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 443 11q23.2 DRD2 dopamine receptor D2 9,45
Mouse 7 444 9 26.72 cM Drd2 dopamine receptor D2 88
Rat 7 444 8q23 Drd2 dopamine receptor D2 9,24
Gene and Protein Information Comments
The human D2 receptor exists as two alternatively spliced isoforms [44]. The 443 amino acid receptor is the long form (D2L). The short form (D2S) is 414 amino acids long.
Previous and Unofficial Names Click here for help
D2A and D2B | dopamine D2 receptor | dopamine receptor 2 | D2 receptor | D2R | D2(415) and D2(444)
Database Links Click here for help
Specialist databases
GPCRdb drd2_human (Hs), drd2_mouse (Mm), drd2_rat (Rn)
Other databases
Alphafold P14416 (Hs), P61168 (Mm), P61169 (Rn)
ChEMBL Target CHEMBL217 (Hs), CHEMBL3427 (Mm), CHEMBL339 (Rn)
DrugBank Target P14416 (Hs)
Ensembl Gene ENSG00000149295 (Hs), ENSMUSG00000032259 (Mm), ENSRNOG00000008428 (Rn)
Entrez Gene 1813 (Hs), 13489 (Mm), 24318 (Rn)
Human Protein Atlas ENSG00000149295 (Hs)
KEGG Gene hsa:1813 (Hs), mmu:13489 (Mm), rno:24318 (Rn)
OMIM 126450 (Hs)
Orphanet ORPHA121177 (Hs)
Pharos P14416 (Hs)
RefSeq Nucleotide NM_000795 (Hs), NM_010077 (Mm), NM_012547 (Rn)
RefSeq Protein NP_000786 (Hs), NP_034207 (Mm), NP_036679 (Rn)
UniProtKB P14416 (Hs), P61168 (Mm), P61169 (Rn)
Wikipedia DRD2 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
PDB Id:  6CM4
Ligand:  risperidone
Resolution:  2.9Å
Species:  Human
References:  132
Natural/Endogenous Ligands Click here for help
dopamine

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Agonists
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Ligand Sp. Action Value Parameter Reference
rotigotine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Agonist 10.2 pKi 37
⤷ pKi 10.2 (Ki 6x10-11 M) [37]
aripiprazole Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Rn Partial agonist 9.7 pKi 104
⤷ pKi 9.7 [104]
brexpiprazole Small molecule or natural product Approved drug Hs Partial agonist 9.5 pKi 76
⤷ pKi 9.5 (Ki 3x10-10 M) [76]
lisuride Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Partial agonist 9.2 – 9.5 pKi 86
⤷ pKi 9.2 – 9.5 [86]
aripiprazole Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Partial agonist 9.1 pKi 138
⤷ pKi 9.1 (Ki 8x10-10 M) [138]
cabergoline Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Partial agonist 9.0 – 9.2 pKi 86
⤷ pKi 9.0 – 9.2 [86]
terguride Small molecule or natural product Approved drug Click here for species-specific activity table Hs Partial agonist 9.1 pKi 86
⤷ pKi 9.1 [86]
roxindole Small molecule or natural product Click here for species-specific activity table Hs Partial agonist 8.6 pKi 86
⤷ pKi 8.6 [86]
UNC9975 Small molecule or natural product Hs Biased agonist 8.6 pKi 3
⤷ pKi 8.6 (Ki 2.6x10-9 M) [3]
Description: β-arrestin 2 biased agonist.
UNC0006 Small molecule or natural product Hs Biased agonist 8.3 pKi 3
⤷ pKi 8.3 (Ki 5x10-9 M) [3]
Description: β-arrestin 2 biased agonist.
cariprazine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Partial agonist 8.2 pKi 1
⤷ pKi 8.2 (Ki 5.7x10-9 M) [1]
Description: Binding affinity to human dopamine D2L receptor
MLS1547 Small molecule or natural product Hs Biased agonist 8.2 pKi 40
⤷ pKi 8.2 (Ki 5.9x10-9 M) [40]
Description: Biased agonist for G-protein coupling to Gi.
(-)-N-porphynorapomorphine Small molecule or natural product Click here for species-specific activity table Hs Full agonist 7.5 – 8.9 pKi 41,102
⤷ pKi 7.5 – 8.9 [41,102]
ropinirole Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Agonist 8.1 pKi 49
⤷ pKi 8.1 (Ki 7.2x10-9 M) [49]
LP-44 Small molecule or natural product Click here for species-specific activity table Hs Agonist 8.1 pKi 71
⤷ pKi 8.1 (Ki 7.3x10-9 M) [71]
sumanirole Small molecule or natural product Hs Full agonist 8.1 pKi 83
⤷ pKi 8.1 (Ki 9x10-9 M) [83]
bromocriptine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 7.3 – 8.3 pKi 41,86,102
⤷ pKi 7.3 – 8.3 [41,86,102]
apomorphine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Rn Partial agonist 7.6 pKi 120
⤷ pKi 7.6 [120]
pergolide Small molecule or natural product Approved drug Click here for species-specific activity table Hs Full agonist 7.5 – 7.6 pKi 86
⤷ pKi 7.5 – 7.6 [86]
bromocriptine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Rn Partial agonist 7.3 pKi 120
⤷ pKi 7.3 [120]
UNC9994 Small molecule or natural product Hs Biased agonist 7.1 pKi 3
⤷ pKi 7.1 (Ki 7.9x10-8 M) [3]
Description: β-arrestin 2 biased agonist.
compound 3 [PMID: 23134120] Small molecule or natural product Click here for species-specific activity table Hs Agonist 6.9 pKi 121
⤷ pKi 6.9 (Ki 1.18x10-7 M) [121]
piribedil Small molecule or natural product Click here for species-specific activity table Hs Partial agonist 6.8 – 6.9 pKi 86
⤷ pKi 6.8 – 6.9 [86]
LP-211 Small molecule or natural product Click here for species-specific activity table Hs Agonist 6.8 pKi 72
⤷ pKi 6.8 (Ki 1.42x10-7 M) [72]
LP-12 Small molecule or natural product Click here for species-specific activity table Hs Agonist 6.7 pKi 71
⤷ pKi 6.7 (Ki 2.24x10-7 M) [71]
apomorphine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Partial agonist 5.7 – 7.5 pKi 25,41,86,102,118
⤷ pKi 5.7 – 7.5 [25,41,86,102,118]
7-OH-DPAT Small molecule or natural product Click here for species-specific activity table Hs Full agonist 5.6 – 7.6 pKi 25,41,75
⤷ pKi 5.6 – 7.6 [25,41,75]
HS665 Small molecule or natural product Click here for species-specific activity table Hs Agonist 6.3 pKi 121
⤷ pKi 6.3 (Ki 4.5x10-7 M) [121]
quinpirole Small molecule or natural product Click here for species-specific activity table Hs Full agonist 4.9 – 7.7 pKi 25,85,92,118,120,129
⤷ pKi 4.9 – 7.7 [25,85,92,118,120,129]
pramipexole Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 5.1 – 7.4 pKi 85,102
⤷ pKi 5.1 – 7.4 [85,102]
7-OH-DPAT Small molecule or natural product Rn Full agonist 6.2 pKi 33
⤷ pKi 6.2 [33]
dopamine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Immunopharmacology Ligand Hs Full agonist 4.7 – 7.2 pKi 25,41,102
⤷ pKi 4.7 – 7.2 [25,41,102]
PD 128907 Small molecule or natural product Click here for species-specific activity table Hs Full agonist 5.4 – 6.4 pKi 94,102
⤷ pKi 5.4 – 6.4 [94,102]
dopamine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Immunopharmacology Ligand Rn Full agonist 5.3 – 6.4 pKi 104,120
⤷ pKi 5.3 – 6.4 [104,120]
7-trans-OH-PIPAT Small molecule or natural product Click here for species-specific activity table Hs Full agonist 5.6 pKi 33
⤷ pKi 5.6 [33]
quinelorane Small molecule or natural product Click here for species-specific activity table Hs Full agonist 5.5 – 5.7 pKi 87,118
⤷ pKi 5.5 – 5.7 [87,118]
benzquinamide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Agonist 5.4 pKi 46
⤷ pKi 5.4 (Ki 3.964x10-6 M) [46]
quinpirole Small molecule or natural product Click here for species-specific activity table Rn Full agonist 5.2 pKi 120
⤷ pKi 5.2 [120]
UNC9975 Small molecule or natural product Hs Biased agonist 9.0 pEC50 3
⤷ pEC50 9.0 (EC50 1.1x10-9 M) [3]
Description: This compound shows biased agonism towards D2-mediated β-arrestin-2 translocation measured using the Tango assay.
UNC0006 Small molecule or natural product Hs Biased agonist 8.9 pEC50 3
⤷ pEC50 8.9 (EC50 1.2x10-9 M) [3]
Description: Biased agonist of D2-mediated β-arrestin-2 translocation measured using the Tango assay.
UNC9994 Small molecule or natural product Hs Biased agonist 8.2 pEC50 3
⤷ pEC50 8.2 (EC50 6.1x10-9 M) [3]
Description: This compound shows biased agonism towards D2-mediated β-arrestin-2 translocation measured using the Tango assay.
aripiprazole Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Partial agonist 7.4 pEC50 3
⤷ pEC50 7.4 (EC50 3.8x10-8 M) [3]
Description: Measuring cAMP production via the Gi-coupled signaling pathway
vilazodone Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Agonist 6.2 pIC50 51
⤷ pIC50 6.2 (IC50 6.66x10-7 M) [51]
View species-specific agonist tables
Agonist Comments
Terguride and roxindole have been reported to be partial agonists at the D2S receptor and antagonists at the D2L receptor.
Although benzquinamide has higher affinity for α-adrenoceptors, it is suggested in [46] that it is more likely that drug-induced modulation of D2 receptor activity is responsible for the drug's antiemetic action.
Allosteric modulation of the D2 receptor by SB269652 only occurs when D2 receptor dimers form, with the ligand assuming a 'bitopic' pose and interacting with different sites on each of the two protomers in the dimer [70].
UNC0006, UNC9994 and UNC9975 are partial biased agonists of β-arrestin 2 recruitment at the D2 receptor as measured using three different assays (β-arrestin-2 translocation Tango assay, DiscoveRx assay and BRET-based β-arrestin-2 recruitment assay) [3]. Tango assay pEC50 values and binding Kis are provided in the table above.
G protein-biased, cariprazine-based partial agonists are reported in [115].
Antagonists
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Ligand Sp. Action Value Parameter Reference
[3H]nemonapride Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Ligand has a PDB structure Hs Antagonist 10.9 pKd 77
⤷ pKd 10.9 [77]
[3H]spiperone Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Ligand has a PDB structure Rn Antagonist 10.2 pKd 24,52,141
⤷ pKd 10.2 (Kd 5.7x10-11 M) [24,52,141]
[3H]raclopride Small molecule or natural product Ligand is labelled Ligand is radioactive Rn Antagonist 8.9 pKd 67
⤷ pKd 8.9 (Kd 1.2x10-9 M) [67]
[3H]N-methylspiperone Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Rn Antagonist 10.7 pKi 104
⤷ pKi 10.7 [104]
benperidol Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 10.6 pKi 111
⤷ pKi 10.6 (Ki 2.7x10-11 M) [111]
blonanserin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 9.9 pKi 90
⤷ pKi 9.9 (Ki 1.4x10-10 M) [90]
pipotiazine Small molecule or natural product Approved drug Primary target of this compound Hs Antagonist 9.7 pKi 119
⤷ pKi 9.7 (Ki 2x10-10 M) [119]
risperidone Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 9.4 pKi 11
⤷ pKi 9.4 (Ki 4.4x10-10 M) [11]
perphenazine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 8.9 – 9.6 pKi 64,108
⤷ pKi 8.9 – 9.6 (Ki 1.4x10-9 – 2.6x10-10 M) [64,108]
perospirone Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 9.2 pKi 109
⤷ pKi 9.2 (Ki 6x10-10 M) [109]
eticlopride Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 9.2 pKi 75,125
⤷ pKi 9.2 [75,125]
trifluoperazine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 8.9 – 9.0 pKi 64,110
⤷ pKi 8.9 – 9.0 (Ki 1.3x10-9 – 9.6x10-10 M) [64,110]
asenapine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 8.9 pKi 114
⤷ pKi 8.9 (Ki 1.2x10-9 M) [114]
terguride Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 8.9 pKi 86
⤷ pKi 8.9 [86]
spiperone Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Antagonist 8.4 – 9.4 pKi 75,87,120,125
⤷ pKi 8.4 – 9.4 [75,87,120,125]
fluphenazine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 8.8 pKi 101
⤷ pKi 8.8 (Ki 1.44x10-9 M) [101]
flupentixol Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 8.8 pKi 41
⤷ pKi 8.8 (Ki 1.5x10-9 M) [41]
nafadotride Small molecule or natural product Click here for species-specific activity table Rn Antagonist 8.8 pKi 104
⤷ pKi 8.8 [104]
lurasidone Small molecule or natural product Approved drug Click here for species-specific activity table Rn Antagonist 8.8 pKi 55
⤷ pKi 8.8 (Ki 1.68x10-9 M) [55]
olanzapine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 8.7 pKi 11
⤷ pKi 8.7 (Ki 2.1x10-9 M) [11]
mesoridazine Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 8.7 pKi 32
⤷ pKi 8.7 (Ki 2.2x10-9 M) [32]
roxindole Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.6 pKi 86
⤷ pKi 8.6 [86]
ziprasidone Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 8.6 pKi 11
⤷ pKi 8.6 (Ki 2.8x10-9 M) [11]
chlorprothixene Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 8.5 pKi 130
⤷ pKi 8.5 (Ki 2.96x10-9 M) [130]
nafadotride Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.5 pKi 103
⤷ pKi 8.5 [103]
raclopride Small molecule or natural product Click here for species-specific activity table Rn Antagonist 7.7 – 9.3 pKi 104,120
⤷ pKi 7.7 – 9.3 [104,120]
domperidone Small molecule or natural product Approved drug Click here for species-specific activity table Rn Antagonist 8.5 pKi 120
⤷ pKi 8.5 [120]
sertindole Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 8.0 – 8.9 pKi 63-64,108
⤷ pKi 8.0 – 8.9 (Ki 9.1x10-9 – 1.2x10-9 M) [63-64,108]
prochlorperazine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 8.4 pKi 13
⤷ pKi 8.4 (Ki 3.61x10-9 M) [13]
haloperidol Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Rn Antagonist 8.3 pKi 120
⤷ pKi 8.3 [120]
(+)-sulpiride Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.2 pKi 41
⤷ pKi 8.2 (Ki 6x10-9 M) [41]
L-741,626 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.9 – 8.5 pKi 47,66
⤷ pKi 7.9 – 8.5 [47,66]
domperidone Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 7.9 – 8.4 pKi 41,118
⤷ pKi 7.9 – 8.4 (Ki 1.26x10-8 – 3.98x10-9 M) [41,118]
loxapine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 7.9 – 8.3 pKi 64,110
⤷ pKi 7.9 – 8.3 (Ki 1.2x10-8 – 5x10-9 M) [64,110]
(+)-butaclamol Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.5 – 8.7 pKi 25,41,75,125
⤷ pKi 7.5 – 8.7 [25,41,75,125]
haloperidol Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 7.4 – 8.8 pKi 41,75,85,118,126
⤷ pKi 7.4 – 8.8 [41,75,85,118,126]
raclopride Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.0 pKi 87
⤷ pKi 8.0 (Ki 1x10-8 M) [87]
zotepine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 8.0 pKi 107
⤷ pKi 8.0 (Ki 1.1x10-8 M) [107]
(-)-stepholidine Small molecule or natural product Hs Antagonist 7.9 pKi 84
⤷ pKi 7.9 (Ki 1.16x10-8 M) [84]
pimozide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 7.0 – 8.8 pKi 41,118
⤷ pKi 7.0 – 8.8 [41,118]
amisulpride Small molecule or natural product Approved drug Primary target of this compound Hs Antagonist 7.8 – 8.0 pKi 79,118,120
⤷ pKi 7.9 – 8.0 [79,118]
pKi 7.8 [120]
cinnarizine Small molecule or natural product Approved drug Ligand has a PDB structure Rn Antagonist 7.9 pKi 58
⤷ pKi 7.9 (Ki 1.32x10-8 M) [58]
flunarizine Small molecule or natural product Approved drug Rn Antagonist 6.9 – 8.4 pKi 4,58
⤷ pKi 6.9 – 8.4 (Ki 1.12x10-7 – 3.96x10-9 M) [4,58]
pimozide Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Rn Antagonist 7.6 pKi 120
⤷ pKi 7.6 [120]
sulpiride Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 7.2 – 7.9 pKi 25
⤷ pKi 7.2 – 7.9 (Ki 6x10-8 – 1.2x10-8 M) [25]
metoclopramide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Mm Antagonist 7.5 pKi 81
⤷ pKi 7.5 (Ki 2.88x10-8 M) [81]
chlorpromazine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Rn Antagonist 7.5 pKi 120
⤷ pKi 7.5 [120]
lumateperone Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 7.5 pKi 73,117
⤷ pKi 7.5 (Ki 3.2x10-8 M) [73,117]
chlorpromazine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 7.0 – 7.6 pKi 41,118
⤷ pKi 7.0 – 7.6 [41,118]
quetiapine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 7.2 pKi 11
⤷ pKi 7.2 (Ki 6.9x10-8 M) [11]
(-)-sulpiride Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 6.3 – 8.0 pKi 41,118,125
⤷ pKi 6.3 – 8.0 (Ki 5.2x10-7 – 1x10-8 M) [41,118,125]
R-VK4-40 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.1 pKi 57
⤷ pKi 7.1 (Ki 7.58x10-8 M) [57]
(+)-sulpiride Small molecule or natural product Click here for species-specific activity table Rn Antagonist 7.0 pKi 120
⤷ pKi 7.0 [120]
ML321 Small molecule or natural product Primary target of this compound Hs Antagonist 7.0 pKi 135-136
⤷ pKi 7.0 (Ki 1x10-7 M) [135-136]
trans-flupenthixol Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.9 pKi 41
⤷ pKi 6.9 (Ki 1.2x10-7 M) [41]
EGIS-11150 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.9 pKi 42
⤷ pKi 6.9 (Ki 1.2x10-7 M) [42]
(+)-UH232 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.4 – 7.1 pKi 41,120
⤷ pKi 6.4 – 7.1 [41,120]
promazine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 6.5 pKi 26
⤷ pKi 6.5 (Ki 3x10-7 M) [26]
(+)-UH232 Small molecule or natural product Click here for species-specific activity table Rn Antagonist 6.4 pKi 120
⤷ pKi 6.4 [120]
clozapine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 5.8 – 6.9 pKi 41,75,114,118,125
⤷ pKi 5.8 – 6.9 [41,75,114,118,125]
clozapine Small molecule or natural product Approved drug Click here for species-specific activity table Rn Antagonist 6.2 pKi 120
⤷ pKi 6.2 [120]
(+)-S-14297 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 5.5 pKi 87
⤷ pKi 5.5 [87]
(+)-SCH-23390 Small molecule or natural product Hs Antagonist 5.3 pKi 41
⤷ pKi 5.3 [41]
iloperidone Small molecule or natural product Approved drug Click here for species-specific activity table Rn Antagonist 7.0 pIC50 123
⤷ pIC50 7.0 (IC50 1.1x10-7 M) [123]
Description: Measuring displacement of [3H]spiperone from rat striatum.
metopimazine Small molecule or natural product Approved drug N/A Antagonist - -
⤷
alizapride Small molecule or natural product Approved drug N/A Antagonist - -
⤷
View species-specific antagonist tables
Antagonist Comments
Terguride/roxindole have been reported to act as partial agonists at the D2S receptor and as antagonists at the D2L receptor.
Perphenazine is an antagonist at both the D2S and D2L receptors [124].
The approved drug mesoridazine, although consisting of 4 stereoisomers, appears to be selective for the D2 receptor [32], especially when examining the data for the two highest affinity isomers, compounds 2 and 5. Across the 3 dopamine receptors, compounds 2 and 5 have the same order of potency (D2>D3>D1). The data shown in the table above is for compound 2. Mesoridazine is also a selective antagonist of the serotonin 5-HT2A receptor.
Zotepine has a Ki of 5.4nM for the D2S receptor isoform [107].
The β-arrestin biased ligands UNC9975, UNC0006 and UNC9994, do not activate D2 receptor-mediated Gi-regulated inhibition of cAMP production, but rather are functionally-selective antagonists of the interaction between D2 receptor and β-arrestin-2 [3].
Allosteric Modulators
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Ligand Sp. Action Value Parameter Reference
SB269652 Small molecule or natural product Click here for species-specific activity table Hs Negative 6.4 pKB 70
⤷ pKB 6.4 (KB 4.16x10-7 M) [70]
Description: Allosteric reduction of dopamine binding in a radioligand binding assay
Immunopharmacology Comments
D2 receptor-mediated anti-inflammatory effects in the kidney have a protective effect. In contrast, impaired D2 receptor function results in renal inflammation and organ damage [139]. Taken together with evidence that Drd2 knockout mice have a phenotype that includes a profound brain inflammation, these findings suggest that the dopaminergic system acts as an endogenous, evolutionarily conserved, anti-inflammatory mechanism. Evidence from Han et al. (2017) [48] indicates that D2 receptor-induced anti-inflammatory effects in acute pancreatitis models are mediated via a protein phosphatase 2 (PP2A)-dependent Akt/NF-κB pathway.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process:  Inflammation
Immuno Process:  Antigen presentation
Immuno Process:  Immune regulation
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family
G protein independent mechanism 		Adenylyl cyclase inhibition
Other - See Comments
Comments:  Dopamine D2 receptors can inhibit the Akt (protein kinase B) pathway through a β-arrestin 2/Akt/protein phosphatase 2A complex [15-16].
D2L-induced inhibition of Akt is reported in pituitary lactotrophs, with D2S-induced ERK stimulation also reported in these cells [54,95].
References:  56,89,91
Secondary Transduction Mechanisms Click here for help
Transducer Effector/Response
Potassium channel
Other - See Comments
Comments:  β-arrestin recruitment [40,84,135-136].
References:  31
Tissue Distribution Click here for help
Pituitary, substantia nigra (SN) and ventral tegmental area (VTA).
Species:  Human
Technique:  In situ histochemistry.
References:  43,53
Adrenal cortex.
Species:  Human
Technique:  Autoradiography.
References:  5
Clusters of D2 expressing neurons in limbic and sensory regions of the adult mouse brain cortex.
Species:  Mouse
Technique:  Brain
References:  61
Prelimbic cortex.
Species:  Mouse
Technique:  Confocal analysis in the Bac-GFP reporter mouse.
References:  140
Hippocampus.
Species:  Mouse
Technique:  Bac-GFP reporter mouse.
References:  97
Pityitary (autoradiography), substantia nigra (SN) and ventral tegmental area (VTA) (immunohistochemistry in BAC transgenics).
Species:  Mouse
Technique:  Autoradiography, immunohistochemistry.
References:  50,100
Striatonigral neurons.
Species:  Rat
Technique:  Immunofluorescence.
References:  10
Striatum.
Species:  Rat
Technique:  In situ hybridization.
References:  27
Pituitary, substantia nigra (SN) and ventral tegmental area (VTA).
Species:  Rat
Technique:  In situ histochemistry.
References:  24
Cerebral, mesenteric and renal arteries.
Species:  Rat
Technique:  Autoradiography.
References:  6
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Measurement of cAMP levels in GH4C1 cells transfected with the D2 receptor.
Species:  Rat
Tissue:  GH4C1 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  2
Measurement of prolactin secretion in GH4C1 cells transfected with the D2 receptor.
Species:  Rat
Tissue:  GH4C1 cells.
Response measured:  Inhibition of prolactin secretion.
References:  2
Measurement of voltage-dependent potassium current in NG108-15 cells transfected witht the D2 receptor.
Species:  Rat
Tissue:  NG108-15 cells.
Response measured:  Inhibition of voltage-dependent potassium current.
References:  30
Measurement of activation of potassium channel in rat lactotrophs endogenously expressing the D2 receptor.
Species:  Rat
Tissue:  Lactotrophs.
Response measured:  Activation of potassium channel.
References:  31
Measurement of Ca2+ and cAMP levels in Ltk- cells transfected with both the long and short forms of the human D2 receptor.
Species:  Human
Tissue:  LTK- cells.
Response measured:  Stimulation of calcium mobilisation and cAMP accumulation.
References:  74
Measurement of [3H]thymidine incorporation in CHO cells transfected with the human D2 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  [3H]thymidine incorporation.
References:  69
Measurement of cAMP levels in CHO cells transfected with the human D2 receptor.
Species:  Human
Tissue:  CHO cells.
Response measured:  Inhibition of cAMP accumulation.
References:  69
Measurement of [3H]arachidonic acid release from rat striatal neurons endogenously expressing the D2 receptors.
Species:  Rat
Tissue:  Striatal neurons.
Response measured:  Enhanced [3H]arachidonic acid release.
References:  105
Measurement of cAMP levels in HEK 293 cells transfected with the human D2 receptor.
Species:  Human
Tissue:  HEK 293 cells.
Response measured:  Inhibition of cAMP accumulation.
References:  82,134
Measurement of Cl- currents in Xenopus oocytes transfected with murine D2L and D2S receptors.
Species:  Mouse
Tissue:  Xenopus oocytes.
Response measured:  Stimulation of Cl- influx.
References:  116
Measurement of inwardly rectifying K+ currents in Xenopus oocytes transfected with the human D2 receptor.
Species:  Human
Tissue:  Xenopus oocytes.
Response measured:  Activation of GIRK1 channels.
References:  93
Measurement of inhibition of cAMP dependent transcription using murine D2L and D2S receptors.
Species:  Mouse
Tissue:  HEK293, COS and JEG3 cells.
Response measured: 
References:  89
Physiological Functions Click here for help
Reward effects of morphine.
Species:  Rat
Tissue:  In vivo.
References:  80
Blockade enhances learning/memory.
Species:  Rat
Tissue:  In vivo.
References:  113
Stimulation of accumulation of cAMP in membrane particles of the rat kidney medulla.
Species:  Human
Tissue:  Membrane particles of the rat kidney medulla.
References:  7
Inhibits Na+-K+-adenosinetriphosphatase (ATPase) activity when a D1 agonist is co-administered with a D2 agonist.
Species:  Rat
Tissue:  Proximal tubule.
References:  18
Inhibition of (Na+)+K+)ATPase activity via synergism with the D1 receptor.
Species:  Rat
Tissue:  Isolated striatal neurons.
References:  19
Control of renal blood flow.
Species:  Human
Tissue:  In vivo.
References:  23
Modulation of striatal dopamine.
Species:  Rat
Tissue:  In vivo.
References:  62
Modulation of locomotor activity. (NB rat and mouse)
Species:  Rat
Tissue:  In vivo.
References:  22,122
Physiological Consequences of Altering Gene Expression Click here for help
D2 receptor knockout mice exhibit a decrease in dopamine transporter (DAT) activity.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  36
D2 receptor knockout mice display Parkinsonian-like locomotor impairment when compared to the wild type.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  14,39
D2 receptor knockout mice exhibit abnormal synaptic plasticity.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  29
D2 receptor knockout mice do not exhibit autoreceptor-mediated inhibitory control of dopamine release in striatal synaptosomes, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  68
D2 receptor knockout mice exhibit d-amphetamine-induced disruption of prepulse inhibition, as seen in wild-type mice.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  96
D2 receptor knockout mice are insensitive to the hypolocomotor and hypothermic effects of D2/D3 agonists.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  21
D2 receptor knockout mice are insensitive to the cataleptic effects of haloperidol.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  20
D2 receptor knockout mice exhibit reduced ethanol-conditioned place preference.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  35
D2L receptor knockout mice exhibit reduced aggression.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  131
D2 receptor knockout mice do not exhibit autoinhibition of dopamine release.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  17,98
D2 receptor knockout mice exhibit increased rates of high-dose cocaine self-administration.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  28
D2 receptor knockout mice exhibit reduced locomotor activity and slower acquisition of a place-learning task.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  127
D2 receptor knockout mice exhibit altered dopamine release and uptake.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  106
D2 receptor knockout mice exhibit altered GABAergic neurotransmission.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  8
D2L receptor knockout mice (which still express the short form of the receptor, D2S) exhibit reduced haloperidol-induced catalepsy.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  128,133
D2 receptor knockout mice exhibit hyperprolactinemia.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  12,21,59-60,99-100,137
D2 receptor knockout mice do not show place preference for morphine nor do they self administer the drug.
Species:  Mouse
Tissue: 
Technique:  Gene targeting in embryonic stem cells.
References:  38,78
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0004163 abnormal adenohypophysis morphology PMID: 9247267 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
B6.129S4-Drd2		 MGI:94924  MP:0009745 abnormal behavioral response to xenobiotic PMID: 11069937  12650980 
Drd2+|Drd2tm1Yyw Drd2tm1Yyw/Drd2+
B6.129S4-Drd2		 MGI:94924  MP:0009745 abnormal behavioral response to xenobiotic PMID: 12650980 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0005535 abnormal body temperature PMID: 18486343 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0000913 abnormal brain development PMID: 11158626 
Drd2tm1Mok Drd2tm1Mok/Drd2tm1Mok
involves: 129S/SvEv * C57BL/6J * DBA/2J		 MGI:94924  MP:0005418 abnormal circulating hormone level PMID: 9140068 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0002206 abnormal CNS synaptic transmission PMID: 11158626 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0003119 abnormal digestive system development PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0001663 abnormal digestive system physiology PMID: 15272078 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MP:0001905 abnormal dopamine level PMID: 10391470 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MGI:94925  MP:0001905 abnormal dopamine level PMID: 10391470 
Drd2tm1Schm|Drd3+|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MGI:94925  MP:0001905 abnormal dopamine level PMID: 10391470 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0003271 abnormal duodenum morphology PMID: 15272078 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001927 abnormal estrous cycle PMID: 9247268 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0009016 abnormal estrus PMID: 9247268 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0002910 abnormal excitatory postsynaptic currents PMID: 11158626 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0003245 abnormal GABAergic neuron morphology PMID: 17409246 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001406 abnormal gait PMID: 7566118 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0005645 abnormal hypothalamus physiology PMID: 15272078 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0008802 abnormal intestinal smooth muscle morphology PMID: 15272078 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
B6.Cg-Drd2		 MGI:94924  MP:0006001 abnormal intestinal transit time PMID: 16525059 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
B6.Cg-Drd2 Drd3		 MGI:94924  MGI:94925  MP:0006001 abnormal intestinal transit time PMID: 16525059 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0000477 abnormal intestine morphology PMID: 15272078 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
B6.Cg-Drd2		 MGI:94924  MP:0006003 abnormal large intestinal transit time PMID: 16525059 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
B6.Cg-Drd2 Drd3		 MGI:94924  MGI:94925  MP:0006003 abnormal large intestinal transit time PMID: 16525059 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0006299 abnormal latent inhibition of conditioning behavior PMID: 15061865 
Adora2atm1Jfc|Drd2tm1Low Adora2atm1Jfc/Adora2atm1Jfc,Drd2tm1Low/Drd2tm1Low
involves: 129 * C57BL/6		 MGI:94924  MGI:99402  MP:0003313 abnormal locomotor activation PMID: 16280580 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
involves: 129 * C57BL/6		 MGI:94924  MP:0003313 abnormal locomotor activation PMID: 16280580 
Drd2+|Drd2tm1(IL2RA)Koba Drd2tm1(IL2RA)Koba/Drd2+
B6.129P2-Drd2		 MGI:94924  MP:0003313 abnormal locomotor activation PMID: 14534241 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
involves: 129S2/SvPas * C57BL/6J		 MGI:94924  MP:0003313 abnormal locomotor activation PMID: 9547254 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0003313 abnormal locomotor activation PMID: 11566895  9547254 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
129S/Sv-Drd2		 MGI:94924  MP:0003313 abnormal locomotor activation PMID: 9547254 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MP:0001392 abnormal locomotor activity PMID: 10391470 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MGI:94925  MP:0001392 abnormal locomotor activity PMID: 10391470 
Drd2tm1Schm|Drd3+|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MGI:94925  MP:0001392 abnormal locomotor activity PMID: 10391470 
Drd2+|Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MGI:94925  MP:0001392 abnormal locomotor activity PMID: 10391470 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
involves: 129S2/SvPas * C57BL/6J		 MGI:94924  MP:0001392 abnormal locomotor activity PMID: 9547254 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
involves: 129S2/SvPas * C57BL/6J		 MGI:94924  MP:0001392 abnormal locomotor activity PMID: 9547254 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0001392 abnormal locomotor activity PMID: 10196569  9547254 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0001392 abnormal locomotor activity PMID: 9547254 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
129S/Sv-Drd2		 MGI:94924  MP:0001392 abnormal locomotor activity PMID: 9547254 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
129S/Sv-Drd2		 MGI:94924  MP:0001392 abnormal locomotor activity PMID: 9547254 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008324 abnormal melanotroph morphology PMID: 9717839 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0006009 abnormal neuronal migration PMID: 17409246 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0004811 abnormal neuron physiology PMID: 11069974 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
B6.Cg-Drd2		 MGI:94924  MP:0001666 abnormal nutrient absorption PMID: 16525059 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
B6.Cg-Drd2 Drd3		 MGI:94924  MGI:94925  MP:0001666 abnormal nutrient absorption PMID: 16525059 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0002803 abnormal operant conditional behavior PMID: 15061865 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0000633 abnormal pituitary gland morphology PMID: 9247267 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0005646 abnormal pituitary gland physiology PMID: 9717839 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0003088 abnormal prepulse inhibition PMID: 10341260 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0003462 abnormal response to novel odor PMID: 16765459 
Drd2tm1Mok Drd2tm1Mok/Drd2tm1Mok
involves: 129S/SvEv * C57BL/6J * DBA/2J		 MGI:94924  MP:0003463 abnormal single cell response PMID: 9140068 
Drd2tm1Mok Drd2tm1Mok/Drd2tm1Mok
involves: 129S/SvEv		 MGI:94924  MP:0003463 abnormal single cell response PMID: 14684868 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0000470 abnormal stomach morphology PMID: 15272078 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0000230 abnormal systemic arterial blood pressure PMID: 11566895 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0000230 abnormal systemic arterial blood pressure PMID: 11566895 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0001529 abnormal vocalization PMID: 18382674 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008294 abnormal zona fasciculata morphology PMID: 9717839 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008295 abnormal zona reticularis morphology PMID: 9717839 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0009546 absent gastric milk in neonates PMID: 15272078 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0001899 absent long term depression PMID: 11158626 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008299 adrenal cortical hyperplasia PMID: 9717839 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0002690 akinesia PMID: 7566118 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0002570 alcohol aversion PMID: 10196569 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0001438 aphagia PMID: 15272078 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0001393 ataxia PMID: 10196569 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0001393 ataxia PMID: 10196569 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0005156 bradykinesia PMID: 7566118 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
involves: 129S4/SvJae * C57BL/6		 MGI:94924  MP:0005156 bradykinesia PMID: 11069937 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MP:0005156 bradykinesia PMID: 10391470 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0002822 catalepsy PMID: 7566118 
Drd2+|Drd2tm1Ebo Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0002822 catalepsy PMID: 7566118 
Drd2tm1Mok Drd2tm1Mok/Drd2tm1Mok
involves: 129S/SvEv * C57BL/6J * DBA/2J		 MGI:94924  MP:0005409 darkened coat color PMID: 9140068 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
involves: 129S4/SvJae * C57BL/6J		 MGI:94924  MP:0003862 decreased aggression towards males PMID: 11303741 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0003546 decreased alcohol consumption PMID: 10196569 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
involves: 129S4/SvJae * C57BL/6		 MGI:94924  MP:0001364 decreased anxiety-related response PMID: 11069937 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
B6.129S4-Drd2		 MGI:94924  MP:0001364 decreased anxiety-related response PMID: 11069937 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0001258 decreased body length PMID: 11897683 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MP:0001265 decreased body size PMID: 10391470 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0001265 decreased body size PMID: 15272078 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0005534 decreased body temperature PMID: 7566118 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001262 decreased body weight PMID: 7566118 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MP:0001262 decreased body weight PMID: 10391470 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MGI:94925  MP:0001262 decreased body weight PMID: 10391470 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
B6.Cg-Drd2		 MGI:94924  MP:0001262 decreased body weight PMID: 16525059 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
B6.Cg-Drd2 Drd3		 MGI:94924  MGI:94925  MP:0001262 decreased body weight PMID: 16525059 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0001262 decreased body weight PMID: 10956362 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0001262 decreased body weight PMID: 11897683 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0003371 decreased circulating estrogen level PMID: 9247268 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0005120 decreased circulating growth hormone level PMID: 9247268 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0005120 decreased circulating growth hormone level PMID: 11897683 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0004701 decreased circulating insulin-like growth factor I level PMID: 11897683 
+|Cm|Drd2tm1Low Cm/+,Drd2tm1Low/Drd2tm1Low
involves: 101/H * 129S2/SvPas * C3H/HeH * C3H/HeSn * C57BL/6J		 MGI:88424  MGI:94924  MP:0005643 decreased dopamine level PMID: 19840852 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0003912 decreased drinking behavior PMID: 7566118 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0003910 decreased eating behavior PMID: 7566118 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0003910 decreased eating behavior PMID: 15272078 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0008335 decreased gonadotroph cell number PMID: 9247267 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0009293 decreased inguinal fat pad weight PMID: 11897683 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008423 decreased lactotroph cell size PMID: 9247268 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0003402 decreased liver weight PMID: 11897683 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 9247267 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
involves: 129S2/SvPas * C57BL/6J		 MGI:94924  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 9547254 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0008874 decreased physiological sensitivity to xenobiotic PMID: 18486343 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0005576 decreased pulmonary ventilation PMID: 10956362 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality PMID: 18486343 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008329 decreased somatotroph cell number PMID: 9247268 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0004953 decreased spleen weight PMID: 11897683 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0002757 decreased vertical activity PMID: 7566118 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
involves: 129S4/SvJae * C57BL/6		 MGI:94924  MP:0002757 decreased vertical activity PMID: 11069937 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
B6.129S4-Drd2		 MGI:94924  MP:0002757 decreased vertical activity PMID: 11069937 
Drd2+|Drd2tm1Ebo Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0002757 decreased vertical activity PMID: 7566118 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
involves: 129S2/SvPas * C57BL/6J		 MGI:94924  MP:0002757 decreased vertical activity PMID: 9547254 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0002757 decreased vertical activity PMID: 9547254 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0002757 decreased vertical activity PMID: 9547254 
Drd2tm2Ebo Drd2tm2Ebo/Drd2tm2Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0009746 enhanced behavioral response to xenobiotic PMID: 11089973 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008366 enlarged adenohypophysis PMID: 9247268 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0008366 enlarged adenohypophysis PMID: 9247267 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0000646 enlarged adrenocortical cells PMID: 9717839 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0000636 enlarged pituitary gland PMID: 9247268 
Drd2tm1Mok Drd2tm1Mok/Drd2tm1Mok
involves: 129S/SvEv * C57BL/6J * DBA/2J		 MGI:94924  MP:0008370 enlarged pituitary intermediate lobe PMID: 9140068 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0000465 gastrointestinal hemorrhage PMID: 15272078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0000465 gastrointestinal hemorrhage PMID: 15272078 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MP:0001505 hunched posture PMID: 10391470 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MGI:94925  MP:0001505 hunched posture PMID: 10391470 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001188 hyperpigmentation PMID: 9717839 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001744 hypersecretion of corticosterone PMID: 9717839 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001402 hypoactivity PMID: 7566118 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
involves: 129S4/SvJae * C57BL/6		 MGI:94924  MP:0001402 hypoactivity PMID: 11069937 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
B6.129S4-Drd2		 MGI:94924  MP:0001402 hypoactivity PMID: 11069937 
Drd2+|Drd2tm1Ebo Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001402 hypoactivity PMID: 7566118 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0001402 hypoactivity PMID: 10196569 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0001402 hypoactivity PMID: 10196569 
+|Cm|Drd2tm1Low Cm/+,Drd2tm1Low/Drd2tm1Low
involves: 101/H * 129S2/SvPas * C3H/HeH * C3H/HeSn * C57BL/6J		 MGI:88424  MGI:94924  MP:0001402 hypoactivity PMID: 19840852 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0001402 hypoactivity PMID: 15272078 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0009750 impaired behavioral response to addictive substance PMID: 10341260 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0009755 impaired behavioral response to alcohol PMID: 10196569 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0009755 impaired behavioral response to alcohol PMID: 10196569 
Drd2tm1Yyw Drd2tm1Yyw/Drd2tm1Yyw
involves: 129S4/SvJae * C57BL/6		 MGI:94924  MP:0009747 impaired behavioral response to xenobiotic PMID: 11069937 
Drd2tm2Ebo Drd2tm2Ebo/Drd2tm2Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0009747 impaired behavioral response to xenobiotic PMID: 11089973 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0009712 impaired conditioned place preference behavior PMID: 9252189 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001405 impaired coordination PMID: 7566118 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0001405 impaired coordination PMID: 9547254 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0001260 increased body weight PMID: 11566895 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0005573 increased breathing frequency PMID: 10956362 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001748 increased circulating adrenocorticotropin level PMID: 9717839 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001745 increased circulating corticosterone level PMID: 9717839 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0005117 increased circulating pituitary hormone level PMID: 9717839 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0005124 increased circulating prolactin level PMID: 9247268 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0005124 increased circulating prolactin level PMID: 9247267 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0005124 increased circulating prolactin level PMID: 11897683 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
B6.Cg-Drd2		 MGI:94924  MP:0003867 increased defecation PMID: 16525059 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
B6.Cg-Drd2 Drd3		 MGI:94924  MGI:94925  MP:0003867 increased defecation PMID: 16525059 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
B6.Cg-Drd2		 MGI:94924  MP:0003911 increased drinking behavior PMID: 16525059 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
B6.Cg-Drd2 Drd3		 MGI:94924  MGI:94925  MP:0003911 increased drinking behavior PMID: 16525059 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
B6.Cg-Drd2		 MGI:94924  MP:0003909 increased eating behavior PMID: 16525059 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
B6.Cg-Drd2 Drd3		 MGI:94924  MGI:94925  MP:0003909 increased eating behavior PMID: 16525059 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0003909 increased eating behavior PMID: 11897683 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0005137 increased growth hormone level PMID: 11897683 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0002626 increased heart rate PMID: 11566895 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008331 increased lactotroph cell number PMID: 9247268 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0008331 increased lactotroph cell number PMID: 9247267 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0004875 increased mean systemic arterial blood pressure PMID: 11566895 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0004875 increased mean systemic arterial blood pressure PMID: 11566895 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
involves: 129S2/SvPas * C57BL/6J		 MGI:94924  MP:0008873 increased physiological sensitivity to xenobiotic PMID: 9547254 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0008873 increased physiological sensitivity to xenobiotic PMID: 11566895 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0002041 increased pituitary adenoma incidence PMID: 9247268 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0008939 increased pituitary gland weight PMID: 9247267 
Drd2tm1Mok Drd2tm1Mok/Drd2tm1Mok
involves: 129S/SvEv * C57BL/6J * DBA/2J		 MGI:94924  MP:0003973 increased pituitary hormone level PMID: 9140068 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0005575 increased pulmonary ventilation PMID: 10956362 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008235 increased susceptibility to neuronal excitotoxicity PMID: 11069974 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
B6.129S2-Drd2		 MGI:94924  MP:0008235 increased susceptibility to neuronal excitotoxicity PMID: 11069974 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0002906 increased susceptibility to pharmacologically induced seizures PMID: 11069974 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0006143 increased systemic arterial diastolic blood pressure PMID: 11566895 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0006143 increased systemic arterial diastolic blood pressure PMID: 11566895 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0006144 increased systemic arterial systolic blood pressure PMID: 11566895 
Drd2+|Drd2tm1Low Drd2tm1Low/Drd2+
B6.129S2-Drd2		 MGI:94924  MP:0006144 increased systemic arterial systolic blood pressure PMID: 11566895 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008337 increased thyrotroph cell number PMID: 9247268 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0005585 increased tidal volume PMID: 10956362 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0006316 increased urine sodium level PMID: 11566895 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0000512 intestinal ulcer PMID: 15272078 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001506 limp posture PMID: 7566118 
Drd2+|Drd2tm1(IL2RA)Koba Drd2tm1(IL2RA)Koba/Drd2+
B6.129P2-Drd2		 MGI:94924  MP:0003244 loss of dopaminergic neurons PMID: 14534241 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0000635 pituitary gland hyperplasia PMID: 9247268 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0008371 pituitary intermediate lobe hyperplasia PMID: 9247268  9717839 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2		 MGI:94924  MP:0001762 polyuria PMID: 11566895 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0001732 postnatal growth retardation PMID: 11897683 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0001732 postnatal growth retardation PMID: 15272078 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0001732 postnatal growth retardation PMID: 15272078 
Drd2tm1Schm|Drd3tm1Schm Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MGI:94925  MP:0002082 postnatal lethality PMID: 10391470 
Drd1atm1Jcd|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0002082 postnatal lethality PMID: 15272078 
Drd2tm1Schm Drd2tm1Schm/Drd2tm1Schm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6		 MGI:94924  MP:0002083 premature death PMID: 10391470 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0002083 premature death PMID: 15272078 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0009011 prolonged diestrus PMID: 9247268 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001923 reduced female fertility PMID: 9247268 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001921 reduced fertility PMID: 7566118 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
B6.129S2-Drd2/J		 MGI:94924  MP:0003109 short femur PMID: 11897683 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0009089 short uterine horn PMID: 9247267 
Drd1atm1Jcd|Drd2+|Drd2tm1Ebo Drd1atm1Jcd/Drd1atm1Jcd,Drd2tm1Ebo/Drd2+
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6		 MGI:94924  MGI:99578  MP:0003306 small intestinal inflammation PMID: 15272078 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001127 small ovary PMID: 7566118 
Drd2tm1Ebo Drd2tm1Ebo/Drd2tm1Ebo
involves: 129S2/SvPas * C57BL/6		 MGI:94924  MP:0001147 small testis PMID: 7566118 
Drd2+|Drd2tm1(IL2RA)Koba Drd2tm1(IL2RA)Koba/Drd2+
B6.129P2-Drd2		 MGI:94924  MP:0001396 unidirectional circling PMID: 14534241 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0009221 uterus adenomyosis PMID: 9247267 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0009082 uterus cysts PMID: 9247267 
Drd2tm1Low Drd2tm1Low/Drd2tm1Low
either: B6.129S2-Drd2 or (involves: 129S2/SvPas * C57BL/6)		 MGI:94924  MP:0002676 uterus hyperplasia PMID: 9247267 
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Alcohol dependence
Disease Ontology: DOID:0050741
OMIM: 103780
Disease:  Myoclonic dystonia
OMIM: 159900
Orphanet: ORPHA36899
Biologically Significant Variants Click here for help
Type:  Restriction Fragment Length Polymorphism
Species:  Human
Description:  The TaqI Restriction Fragment Length Polymorphism (RFLP) has been associated with alcoholism.
References:  34
Type:  Restriction Fragment Length Polymorphism
Species:  Human
Description:  TaqI A polymorphism may be associated with ADHD.
References:  112
Type:  Single nucleotide polymorphism
Species:  Human
Description:  Synonymous His313 polymorphism may be associated with schizophrenia.
References:  65
General Comments
The D2 receptor exists as two alternatively spliced isoforms [44], D2L and D2S.

References

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