phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Target id: 2163

Nomenclature: phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Abbreviated Name: PIP4K2C

Family: Phosphatidylinositol phosphate kinases, Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for phosphatidylinositol-5-phosphate 4-kinase type 2 gamma in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 421 12q13.2 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Mouse - 421 10 D3 Pip4k2c phosphatidylinositol-5-phosphate 4-kinase
Rat - 421 7 q22 Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Previous and Unofficial Names
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | PIP4KII-gamma | PIP5K2C | phosphatidylinositol-5-phosphate 4-kinase, type II, gamma | phosphatidylinositol-5-phosphate 4-kinase
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
PDB Id:  2GK9
Resolution:  2.8Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 2.7.1.149
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: PIP5K2C
Ligand Sp. Type Action Affinity Units
foretinib Hs Inhibitor Inhibition 7.6 pKd
BI-2536 Hs Inhibitor Inhibition 7.0 pKd
tamatinib Hs Inhibitor Inhibition 6.9 pKd
PD-173955 Hs Inhibitor Inhibition 6.6 pKd
pazopanib Hs Inhibitor Inhibition 6.6 pKd
imatinib Hs Inhibitor Inhibition 6.4 pKd
TG-100-115 Hs Inhibitor Inhibition 6.3 pKd
PI-103 Hs Inhibitor Inhibition 6.2 pKd
PP-242 Hs Inhibitor Inhibition 6.1 pKd
alvocidib Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol.29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol.17 (11): 1241-9. [PMID:21095574]

How to cite this page

Phosphatidylinositol phosphate kinases: phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. Last modified on 13/08/2015. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2163.